Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway
DC Field | Value | Language |
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dc.contributor.author | Ryu, Joohyun | - |
dc.contributor.author | Cho, Sayeon | - |
dc.contributor.author | Park, Byoung Chul | - |
dc.contributor.author | Lee, Do Hee | - |
dc.date.available | 2019-05-30T01:40:13Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22567 | - |
dc.description.abstract | Although the polyglutamine protein ataxin-1 is modified by SUMO at multiple sites, the functions of such modification or how it is regulated are still unknown. Here we report that SUMO-1 or Ubc9 over-expression stimulated the aggregation of ataxin-1 and that oxidative stress, such as hydrogen peroxide treatment, further enhanced SUMO conjugation and aggregation of ataxin-1. Accordingly, co-treatment with antioxidant N-acetyl-cysteine attenuated the effect of oxidative stress. Ataxin-1, which can activate c-Jun N-terminal kinase (JNK) pathway by itself, strongly associated with apoptosis signal-regulating kinase 1 (ASK1) while not interacting with JNK. Finally, treatment of JNK-specific inhibitor caused a reduction in the oxidant-enhanced SUMOylation and aggregation of ataxin-1. Together these results indicate that SUMO modification of ataxin-1 promotes the aggregation of ataxin-1 and that oxidative stress and JNK pathway play roles in this process. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.01.122 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.393, no.2, pp 280 - 285 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000275946700018 | - |
dc.identifier.scopusid | 2-s2.0-77649184659 | - |
dc.citation.endPage | 285 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 280 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 393 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Polyglutamine diseases | - |
dc.subject.keywordAuthor | Ataxin-1 | - |
dc.subject.keywordAuthor | SUMO-1 | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | ASK1 | - |
dc.subject.keywordPlus | POLYGLUTAMINE-INDUCED DISEASE | - |
dc.subject.keywordPlus | SCA1 TRANSGENIC MICE | - |
dc.subject.keywordPlus | NEURONAL CELL-DEATH | - |
dc.subject.keywordPlus | SUMO MODIFICATION | - |
dc.subject.keywordPlus | MEDIATES NEURODEGENERATION | - |
dc.subject.keywordPlus | NUCLEAR-LOCALIZATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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