The antioxidant and chemopreventive potentialities of Mosidae (Adenophora remotiflora) leaves
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ae-Jung | - |
dc.contributor.author | Han, Myung-Ryun | - |
dc.contributor.author | Kim, Myung-Hwan | - |
dc.contributor.author | Lee, Myoungsook | - |
dc.contributor.author | Yoon, Taek-Joon | - |
dc.contributor.author | Ha, Sang-Do | - |
dc.date.available | 2019-05-30T01:42:14Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22618 | - |
dc.description.abstract | Our study focused on the antioxidant activities of Mosidae leaf ethanol extract (MLE) and included measurements of reducing power, total phenolic compounds, DPPH radical scavenging activity, and hydroxyl radical scavenging activity. In order to determine whether or not MLE evidences any chemopreventive activities, experimental lung metastasis was induced via the i.v. inoculation of colon26-M3.1 carcinoma cells into BALB/c mice. Additionally, we attempted to characterize any possible cytotoxic effects in murine normal splenocytes and tumor cells (B16-BL6 and colon26-M3.1). The total phenolic content and reducing capacity were measured at 39 mg/100 mL and 1.24, respectively, whereas the DPPH and hydroxyl radical scavenging activities of MLE were measured to be 88.89% and 22.10%, respectively. Prophylactic i.v. treatment with MLE resulted in a dose-dependent and significant inhibition of lung metastasis. Specifically, a MLE dose of 200 ug per mouse resulted in an 88.90% inhibition of lung metastasis. For the cytotoxicity assay, MLE doses up to 100 ug/mL were not shown to affect the growth of normal murine splenocytes. Additionally, the survival of normal cells was not affected at MLE doses below 500 ug/mL. However, MLE doses up to 500 ug/mL reduced the percentage of tumor cell growth for B16BL6 (67% alive) and colon26-M3.1 (62% alive) cells. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.title | The antioxidant and chemopreventive potentialities of Mosidae (Adenophora remotiflora) leaves | - |
dc.type | Article | - |
dc.identifier.doi | 10.4162/nrp.2010.4.1.30 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.4, no.1, pp 30 - 35 | - |
dc.identifier.kciid | ART001420877 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000275024700005 | - |
dc.identifier.scopusid | 2-s2.0-78650632885 | - |
dc.citation.endPage | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 30 | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Mosidae (Adenophora remotiflora) leaves | - |
dc.subject.keywordAuthor | antioxidant activity | - |
dc.subject.keywordAuthor | cytotoxicity assay | - |
dc.subject.keywordAuthor | tumor metastasis | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.