Electrochemical Biosensor Composed of Silver Ion-Mediated dsDNA on Au-Encapsulated Bi2Se3 Nanoparticles for the Detection of H2O2 Released from Breast Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Mohammadniaei, Mohsen | - |
dc.contributor.author | Yoon, Jinho | - |
dc.contributor.author | Lee, Taek | - |
dc.contributor.author | Bharate, Bapurao G. | - |
dc.contributor.author | Jo, Jinhee | - |
dc.contributor.author | Lee, Donghyun | - |
dc.contributor.author | Choi, Jeong-Woo | - |
dc.date.available | 2019-03-07T04:45:37Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2263 | - |
dc.description.abstract | A newly developed electrochemical biosensor composed of a topological insulator (TI) and metallic DNA (mDNA) is fabricated. The bismuth selenide nanoparticle (Bi2Se3 NP) is synthesized and sandwiched between the gold electrode and another Au-deposited thin layer (Bi2Se3@Au). Then, eight-silver-ion mediated double-stranded DNA (mDNA) is immobilized onto the substrate (Bi2Se3@Au-mDNA) for the further detection of hydrogen peroxide. The Bi2Se3 NP acts as the electrochemical-signal booster, while unprecedentedly its encapsulation by the Au thin layer keeps the TI surface states protected, improves its electrochemical-signal stability and provides an excellent platform for the subsequent covalent immobilization of the mDNA through Au-thiol interaction. Electrochemical results show that the fabricated biosensor represents much higher Ag+ redox current (approximate to 10 times) than those electrodes prepared without Bi2Se3@Au. The characterization of the Bi2Se3@Au-mDNA film is confirmed by atomic force microscopy, scanning tunneling microscopy, and cyclic voltammetry. The proposed biosensor shows a dynamic range of 00.10 x 10(-6) M to 27.30 x 10(-6) M, very low detection limit (10 x 10(-9) M), unique current response (1.6 s), sound H2O2 recovery in serum, and substantial capability to classify two breast cancer subtypes (MCF-7 and MDA-MB-231) based on their difference in the H2O2 generation, offering potential applications in the biomedicine and pharmacology fields. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Electrochemical Biosensor Composed of Silver Ion-Mediated dsDNA on Au-Encapsulated Bi2Se3 Nanoparticles for the Detection of H2O2 Released from Breast Cancer Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.201703970 | - |
dc.identifier.bibliographicCitation | SMALL, v.14, no.16 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000430398600009 | - |
dc.identifier.scopusid | 2-s2.0-85045830204 | - |
dc.citation.number | 16 | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | bismuth selenide | - |
dc.subject.keywordAuthor | cancer cells | - |
dc.subject.keywordAuthor | electrochemical biosensor | - |
dc.subject.keywordAuthor | extracellular hydrogen peroxide | - |
dc.subject.keywordAuthor | topological insulators | - |
dc.subject.keywordPlus | TOPOLOGICAL INSULATOR NANOSTRUCTURES | - |
dc.subject.keywordPlus | HGTE QUANTUM-WELLS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | HYBRID | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | HEMOGLOBIN | - |
dc.subject.keywordPlus | GRAPHENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ELECTRODE | - |
dc.subject.keywordPlus | SURFACE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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