Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events
DC Field | Value | Language |
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dc.contributor.author | Hien Dang Thanh | - |
dc.contributor.author | Van Trung Tran | - |
dc.contributor.author | Lim, Inseok | - |
dc.contributor.author | Kim, Wonyong | - |
dc.date.available | 2019-03-07T04:45:38Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2266 | - |
dc.description.abstract | After the introduction of two global rotavirus vaccines, RotaTeq in 2007 and Rotarix in 2008 in South Korea, G1[P8] rotavirus was the major rotavirus genotype in the country until 2012. However, in this study, an emergence of G2P[4] as the dominant genotype during the 2013 to 2015 season has been reported. Genetic analysis revealed that these viruses had typical DS-1-like genotype constellation and showed evidence of re-assortment in one or more genome segments, including the incorporation of NSP4 genes from strains B-47/2008 from a cow and R4/Haryana/2007 from a buffalo in India, and the VP1 and VP3 genes from strain GO34/1999 from a goat in Bangladesh. Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-018-24511-y | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000430048000001 | - |
dc.identifier.scopusid | 2-s2.0-85045917538 | - |
dc.citation.number | 1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | GROUP-A ROTAVIRUS | - |
dc.subject.keywordPlus | SEROTYPE-SPECIFIC NEUTRALIZATION | - |
dc.subject.keywordPlus | NATIONAL IMMUNIZATION PROGRAM | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | AMINO-ACID SUBSTITUTIONS | - |
dc.subject.keywordPlus | FULL GENOMIC ANALYSIS | - |
dc.subject.keywordPlus | MOLECULAR EPIDEMIOLOGY | - |
dc.subject.keywordPlus | GENOTYPE CONSTELLATION | - |
dc.subject.keywordPlus | ROTATEQ(R) VACCINE | - |
dc.subject.keywordPlus | STRAINS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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