Zeolite 4A, a Synthetic Silicate, Suppresses Melanogenesis through the Degradation of Microphthalmia-Associated Transcription Factor by Extracellular Signal-Regulated Kinase Activation in B16F10 Melanoma Cells
DC Field | Value | Language |
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dc.contributor.author | Shin, Yong Jae | - |
dc.contributor.author | Han, Chang-Soo | - |
dc.contributor.author | Lee, Chang Seok | - |
dc.contributor.author | Kim, Hong-Sook | - |
dc.contributor.author | Ko, Seong-Hee | - |
dc.contributor.author | Hwang, Seung Kyun | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.contributor.author | Shin, Jong Wook | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Chung, Myung-Hee | - |
dc.date.available | 2019-05-30T02:24:19Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22711 | - |
dc.description.abstract | Zeolite 4A, synthetic silicate, has been shown to exhibit diverse biological activities such as anti-cancer and anti-oxidant activity. In the present study, we report that the zeolite 4A may improve skin-whitening. We found that zeolite 4A inhibited melanin production in a dose-dependent manner, which has not cytotoxicity. Zeolite 4A also inhibited alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin synthesis in B16F10 cells. Interestingly, zeolite 4A decreased alpha-MSH-induced tyrosinase activity in B16F10 cells, which did not inhibit tyrosinase activity under cell-free conditions. The results of this study indicate that zeolite 4A may reduce pigmentation by way of an indirect nonenzymatic mechanism. We also found that zeolite 4A decreased alpha-MSH-induced microphthalmia-associated transcription factor (MITF) and tyrosinase expression and that zeolite 4A induced the activation of extracellular signal-regulated kinase (ERK). These results suggest that the depigmenting effect of zeolite 4A may result from the down-regulation of MITF and tyrosinase expression by increasing ERK activity. The results thus provide evidence that zeolite 4A can be used as a potential skin-whitening agent. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Zeolite 4A, a Synthetic Silicate, Suppresses Melanogenesis through the Degradation of Microphthalmia-Associated Transcription Factor by Extracellular Signal-Regulated Kinase Activation in B16F10 Melanoma Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1248/bpb.33.72 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.1, pp 72 - 76 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000273167800014 | - |
dc.identifier.scopusid | 2-s2.0-75149172375 | - |
dc.citation.endPage | 76 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | zeolite 4A | - |
dc.subject.keywordAuthor | alpha-melanocyte-stimulating hormone | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | microphthalmia-associated transcription factor | - |
dc.subject.keywordAuthor | extracellular signal-regulated kinase | - |
dc.subject.keywordPlus | STIMULATING HORMONE | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | KOJIC ACID | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MITF | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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