A small molecule accelerates neuronal differentiation in the adult rat
DC Field | Value | Language |
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dc.contributor.author | Wurdak, H. | - |
dc.contributor.author | Zhu, S. | - |
dc.contributor.author | Min, K.H. | - |
dc.contributor.author | Aimone, L. | - |
dc.contributor.author | Lairson, L.L. | - |
dc.contributor.author | Watson, J. | - |
dc.contributor.author | Chopiuk, G. | - |
dc.contributor.author | Demas, J. | - |
dc.contributor.author | Charette, B. | - |
dc.contributor.author | Weerapana, E. | - |
dc.contributor.author | Cravatt, B.F. | - |
dc.contributor.author | Cline, H.T. | - |
dc.contributor.author | Peters, E.C. | - |
dc.contributor.author | Zhang, J. | - |
dc.contributor.author | Walker, J.R. | - |
dc.contributor.author | Wu, C. | - |
dc.contributor.author | Chang, J. | - |
dc.contributor.author | Tuntland, T. | - |
dc.contributor.author | Cho, C.Y. | - |
dc.contributor.author | Schultz, P.G. | - |
dc.date.available | 2019-05-30T02:32:34Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22752 | - |
dc.description.abstract | Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain. However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasticity and regeneration. Here, we report the characterization of a small molecule (KHS101) that selectively induces a neuronal differentiation phenotype. Mechanism of action studies revealed a link of KHS101 to cell cycle exit and specific binding to the TACC3 protein, whose knockdown in NPCs recapitulates the KHS101-induced phenotype. Upon systemic administration, KHS101 distributed to the brain and resulted in a significant increase in neuronal differentiation in vivo. Our findings indicate that KHS101 accelerates neuronal differentiation by interaction with TACC3 and may provide a basis for pharmacological intervention directed at endogenous NPCs. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA | - |
dc.title | A small molecule accelerates neuronal differentiation in the adult rat | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.1010300107 | - |
dc.identifier.bibliographicCitation | Proceedings of the National Academy of Sciences of the United States of America, v.107, no.38, pp 16542 - 16547 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000282003700031 | - |
dc.identifier.scopusid | 2-s2.0-78049296965 | - |
dc.citation.endPage | 16547 | - |
dc.citation.number | 38 | - |
dc.citation.startPage | 16542 | - |
dc.citation.title | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.citation.volume | 107 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Adult neurogenesis | - |
dc.subject.keywordAuthor | Neural progenitor cell | - |
dc.subject.keywordAuthor | Tacc3 | - |
dc.subject.keywordPlus | cell protein | - |
dc.subject.keywordPlus | khs 101 | - |
dc.subject.keywordPlus | protein ARNT2 | - |
dc.subject.keywordPlus | thiazole derivative | - |
dc.subject.keywordPlus | transcription factor | - |
dc.subject.keywordPlus | transforming acidic coiled coil containing protein 3 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | basic helix loop helix transcription factor | - |
dc.subject.keywordPlus | KHS101 | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | Neurod1 protein, rat | - |
dc.subject.keywordPlus | thiazole derivative | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cell cycle progression | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | cellular distribution | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug bioavailability | - |
dc.subject.keywordPlus | drug blood level | - |
dc.subject.keywordPlus | drug mechanism | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nerve cell differentiation | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | phenotype | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein binding | - |
dc.subject.keywordPlus | protein interaction | - |
dc.subject.keywordPlus | protein localization | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | adult stem cell | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | cell cycle | - |
dc.subject.keywordPlus | cell differentiation | - |
dc.subject.keywordPlus | chemistry | - |
dc.subject.keywordPlus | cytology | - |
dc.subject.keywordPlus | drug effects | - |
dc.subject.keywordPlus | Fischer 344 rat | - |
dc.subject.keywordPlus | genetics | - |
dc.subject.keywordPlus | hippocampus | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | nerve cell | - |
dc.subject.keywordPlus | nervous system development | - |
dc.subject.keywordPlus | Sprague Dawley rat | - |
dc.subject.keywordPlus | Mammalia | - |
dc.subject.keywordPlus | Rattus | - |
dc.subject.keywordPlus | Adult Stem Cells | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Basic Helix-Loop-Helix Transcription Factors | - |
dc.subject.keywordPlus | Cell Cycle | - |
dc.subject.keywordPlus | Cell Differentiation | - |
dc.subject.keywordPlus | Cell Proliferation | - |
dc.subject.keywordPlus | Cells, Cultured | - |
dc.subject.keywordPlus | Hippocampus | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Neurogenesis | - |
dc.subject.keywordPlus | Neurons | - |
dc.subject.keywordPlus | Phenotype | - |
dc.subject.keywordPlus | Rats | - |
dc.subject.keywordPlus | Rats, Inbred F344 | - |
dc.subject.keywordPlus | Rats, Sprague-Dawley | - |
dc.subject.keywordPlus | RNA, Messenger | - |
dc.subject.keywordPlus | Thiazoles | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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