3T3-L1 세포의 지방세포형성과정에서 Baicalin에 의한 유전자 발현 프로파일 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이해용 | - |
dc.contributor.author | 강련화 | - |
dc.contributor.author | 정상인 | - |
dc.contributor.author | 조수현 | - |
dc.contributor.author | 윤유식 | - |
dc.date.available | 2019-05-30T02:32:50Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.issn | 2288-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22758 | - |
dc.description.abstract | Baicalin, a flavonoid, was shown to have diverse effects such as anti-inflammatory, anti-cancer, anti-viral, anti-bacterial and others. Recently, we found that the baicalin inhibits adipogenesis through the modulations of anti-adipogenic and pro-adipogenic factors of the adipogenesis pathway. In the present study, we further characterized the molecular mechanism of the anti-adipogenic effect of baicalin using microarray technology. Microarray analyses were conducted to analyze the gene expression profiles during the differentiation time course (0 day, 2 day, 4 day and 7 day) in 3T3-L1 cells with or without baicalin treatment. We identified a total of 3972 genes of which expressions were changed more than 2 fold. These 3972 genes were further analyzed using hierarchical clustering analysis, resulting in 20 clusters. Four clusters among 20 showed clearly up-regulated expression patterns (cluster 8 and cluster 10) or clearly down-regulated expression patterns (cluster 12 and cluster 14) by baicalin treatment for over-all differentiation period. The cluster 8 and cluster 10 included many genes which enhance cell proliferation or inhibit adipogenesis. On the other hand, the cluster 12 and cluster 14 included many genes which are related with proliferation inhibition, cell cycle arrest, cell growth suppression or adipogenesis induction. In conclusion, these data provide detailed information on the molecular mechanism of baicalin-induced inhibition of adipogenesis. | - |
dc.format.extent | 10 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국식품영양과학회 | - |
dc.title | 3T3-L1 세포의 지방세포형성과정에서 Baicalin에 의한 유전자 발현 프로파일 분석 | - |
dc.title.alternative | Effects of Baicalin on Gene Expression Profiles during Adipogenesis of 3T3-L1 Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3746/jkfn.2010.39.1.054 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Food Science and Nutrition, v.39, no.1, pp 54 - 63 | - |
dc.identifier.kciid | ART001416582 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-77957706617 | - |
dc.citation.endPage | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.title | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.volume | 39 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Baicalin | - |
dc.subject.keywordAuthor | Gene expression profile | - |
dc.subject.keywordAuthor | Microarray | - |
dc.subject.keywordPlus | Bacteria (microorganisms) | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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