Protective Effect of Resveratrol on Agonist-Dependent Regulation of Vascular Contractility via Inhibition of Rho-Kinase Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Je, Hyun Dong | - |
dc.contributor.author | Lee, Myeong Hwan | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Park, Sun Young | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-05-30T02:34:38Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.issn | 1423-0313 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22791 | - |
dc.description.abstract | The present study was undertaken to investigate the influence of resveratrol on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Resveratrol at a low concentration (0.03 mmol/l) relaxed directly and more markedly fluoride-induced vascular contraction than phorbol ester-induced contraction. Furthermore, resveratrol more markedly inhibited fluoride-induced increases in pMYPT1 levels than phorbol ester-induced increases. It also more markedly inhibited fluoride-induced increases in pMYPT1 levels than pERK1/2 levels, suggesting that the mechanism involved the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1. This study provides evidence regarding the mechanism underlying the relaxation effect of resveratrol on agonist-induced vascular contraction regardless of endothelial function. Copyright (C) 2010 S. Karger AG, Basel | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Protective Effect of Resveratrol on Agonist-Dependent Regulation of Vascular Contractility via Inhibition of Rho-Kinase Activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000312665 | - |
dc.identifier.bibliographicCitation | PHARMACOLOGY, v.86, no.1, pp 37 - 43 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000280684100006 | - |
dc.identifier.scopusid | 2-s2.0-77953933245 | - |
dc.citation.endPage | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.title | PHARMACOLOGY | - |
dc.citation.volume | 86 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | ERK1/2 | - |
dc.subject.keywordAuthor | Fluoride | - |
dc.subject.keywordAuthor | MYPT1 | - |
dc.subject.keywordAuthor | Phorbol ester | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | Rho-kinase | - |
dc.subject.keywordAuthor | Vasodilation | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE CONTRACTION | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | RED WINE | - |
dc.subject.keywordPlus | DIETARY POLYPHENOLS | - |
dc.subject.keywordPlus | MYOSIN PHOSPHATASE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CA2+ ENTRY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.