Chitooligosaccharide Copolymers: Synthesis and Aqueous Self-assembly
DC Field | Value | Language |
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dc.contributor.author | Zhao, Sanping | - |
dc.contributor.author | Lee, Min-Kyung | - |
dc.contributor.author | Lee, Jonghwi | - |
dc.date.available | 2019-05-30T02:34:51Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1060-1325 | - |
dc.identifier.issn | 1520-5738 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22798 | - |
dc.description.abstract | Novel water-soluble amphiphilic graft copolymers (COS-g-PCL-b-MPEG) were synthesized by the coupling reaction between chitooligosaccharide (COS) and MPEG-b-PCL-COOH, which was synthesized via ring-opening polymerization of epsilon-caprolactone (CL) using MPEG as an initiator and subsequent carboxylation by succinic anhydride. The chemical composition of the graft copolymers was confirmed by 1H-NMR spectra and FT-IR spectrometry. The thermal properties and crystallinity of the copolymers were observed by DSC and XRD measurements, which showed the existence of separate backbone and graft chain phases in the copolymer. The micellar behavior via self-assembly of the graft copolymers in aqueous solution was studied using pyrene fluorescence dye technique. AFM measurements showed that the micelles had a spherical morphology at the critical micelle concentration (CMC) and ranged in size from 20-45 nm. The amphiphilic ternary biodegradable graft copolymer endows the hydrophilic outer shell of micelles with structural and functional diversification, which might be desirable for drug delivery applications. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | Chitooligosaccharide Copolymers: Synthesis and Aqueous Self-assembly | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/10601321003741982 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, v.47, no.6, pp 580 - 587 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000277588600012 | - |
dc.identifier.scopusid | 2-s2.0-77951744672 | - |
dc.citation.endPage | 587 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 580 | - |
dc.citation.title | JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Chitooligosaccharide | - |
dc.subject.keywordAuthor | graft copolymer | - |
dc.subject.keywordAuthor | micelle | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | water-soluble polymer | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | TRIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ALPHA-CYCLODEXTRIN | - |
dc.subject.keywordPlus | INCLUSION COMPLEXATION | - |
dc.subject.keywordPlus | POLY(ETHYLENE OXIDE) | - |
dc.subject.keywordPlus | DIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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