ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES
DC Field | Value | Language |
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dc.contributor.author | Lee, S. H. | - |
dc.contributor.author | Kim, K-Y | - |
dc.contributor.author | Ryu, S. Y. | - |
dc.contributor.author | Yoon, Y. | - |
dc.contributor.author | Hahm, D-H | - |
dc.contributor.author | Kang, S. A. | - |
dc.contributor.author | Cho, S. H. | - |
dc.contributor.author | Lim, J-S | - |
dc.contributor.author | Moon, E-Y | - |
dc.contributor.author | Yoon, S. R. | - |
dc.contributor.author | Lee, H. G. | - |
dc.contributor.author | Yoon, D. Y. | - |
dc.contributor.author | Yang, Y. | - |
dc.date.available | 2019-05-30T02:36:02Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.issn | 1165-158X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22827 | - |
dc.description.abstract | Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPAR gamma and C/EBP alpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | C M B ASSOC | - |
dc.title | ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES | - |
dc.type | Article | - |
dc.identifier.doi | 10.1170/138 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR BIOLOGY, v.56, no.SUPPL.1, pp 1215 - 1222 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000274570400001 | - |
dc.identifier.scopusid | 2-s2.0-77951913517 | - |
dc.citation.endPage | 1222 | - |
dc.citation.number | SUPPL.1 | - |
dc.citation.startPage | 1215 | - |
dc.citation.title | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 56 | - |
dc.type.docType | Article | - |
dc.publisher.location | 프랑스 | - |
dc.subject.keywordAuthor | C/EBP alpha | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.subject.keywordAuthor | Adiponectin | - |
dc.subject.keywordAuthor | Asarone | - |
dc.subject.keywordAuthor | Hormone-sensitive lipase | - |
dc.subject.keywordPlus | HORMONE-SENSITIVE LIPASE | - |
dc.subject.keywordPlus | ADIPOSE TRIGLYCERIDE LIPASE | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | FATTY-ACID OXIDATION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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