Multipotent Progenitor Cells Derived From Human Umbilical Cord Blood Can Differentiate Into Hepatocyte-Like Cells in a Liver Injury Rat Model
DC Field | Value | Language |
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dc.contributor.author | Moon, Y. J. | - |
dc.contributor.author | Yoon, H. H. | - |
dc.contributor.author | Lee, M. W. | - |
dc.contributor.author | Jang, I. K. | - |
dc.contributor.author | Lee, D. -H. | - |
dc.contributor.author | Lee, J. -H. | - |
dc.contributor.author | Lee, S. -K. | - |
dc.contributor.author | Lee, K. -H. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Eom, Y. -W. | - |
dc.date.available | 2019-05-30T02:36:51Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.issn | 1873-2623 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22848 | - |
dc.description.abstract | Umbilical cord blood (UCB), a rich source of hematopoietic stem cells, offers practical and ethical advantages. It has been reported that various adult stem cells transplanted into a damaged liver show characteristics of a hepatic lineage. In a previous study, we reported on novel UCB-derived adult stem cells, termed umbilical cord blood-derived multipotent progenitor cells (UCB-MPCs). We demonstrated that these cells were capable of differentiating into hepatocyte-like cells in vitro. To assess the hepatic differentiation capacity of UCB-MPCs, rat models of hepatic injury were generated using carbon tetra-chloride (CC14) with transplantation of cells into the liver. The transplanted cells successfully incorporated into the liver of the recipient animal differentiated into functional hepatocyte-like cells that expressed hepatocyte-specific markers, such as CK-18 and albumin. Moreover, human albumin was detected in the serum of the recipient rat model. These data indicated that UCB-MPCs were capable of displaying similar characteristics to those of functional hepatocytes in a recipient liver. UCB-MPCs may prove to be a useful, transplantable alternative for hepatic progenitor cells in both experimental and therapeutic applications. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Multipotent Progenitor Cells Derived From Human Umbilical Cord Blood Can Differentiate Into Hepatocyte-Like Cells in a Liver Injury Rat Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.transproceed.2009.08.053 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, v.41, no.10, pp 4357 - 4360 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000272968800064 | - |
dc.identifier.scopusid | 2-s2.0-71249108264 | - |
dc.citation.endPage | 4360 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4357 | - |
dc.citation.title | TRANSPLANTATION PROCEEDINGS | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MOUSE-LIVER | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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