Effects of a Preparation of Combined Glutathione-Enriched Yeast and Rice Embryo/Soybean Extracts on Ethanol Hangover
DC Field | Value | Language |
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dc.contributor.author | Lee, Heon-Sik | - |
dc.contributor.author | Song, Jugyeong | - |
dc.contributor.author | Kim, Tae Myoung | - |
dc.contributor.author | Joo, Seong Soo | - |
dc.contributor.author | Park, Dongsun | - |
dc.contributor.author | Jeon, Jeong Hee | - |
dc.contributor.author | Shin, Sunhee | - |
dc.contributor.author | Park, Hyoung Kook | - |
dc.contributor.author | Lee, Won Kyung | - |
dc.contributor.author | Ly, Sun Yung | - |
dc.contributor.author | Kim, Mee Ree | - |
dc.contributor.author | Lee, Do Ik | - |
dc.contributor.author | Kim, Yun-Bae | - |
dc.date.available | 2019-05-30T02:37:42Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.issn | 1557-7600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22873 | - |
dc.description.abstract | The effects of a preparation of combined glutathione-enriched yeast (GEY) and rice embryo/soybean (RES) extracts (20:1), GEY/RES, on experimentally induced ethanol hangover were investigated in male Sprague-Dawley rats. To evaluate the preventive effects on hangover, rats were orally administered GEY/RES (50/2.5, 100/5, or 200/10 mg/kg) for 2 weeks. At 30 minutes after the final treatment, they were challenged with 3 mL/kg ethanol (15 mL of 20% in water/kg). The blood concentrations of alcohol and acetaldehyde were analyzed up to 7 hours postchallenge. Hepatic mRNA expression levels of alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH), cytochrome P450 type 2E1 (CYP2E1), and aldehyde dehydrogenase (ALDH), were determined by real-time polymerase chain reaction. Additional rats were challenged with ethanol and, 60 minutes later, administered GEY/RES to evaluate alcohol clearance. Pretreatment with GEY/RES for 2 weeks reduced the blood concentrations of alcohol and acetaldehyde in a dose-dependent manner, lowering by 29.5% and 54.6% at the highest dose (200/10 mg/kg), respectively. The expressions of mRNAs for ADH and ALDH, the major alcohol-metabolizing enzymes, were markedly increased in the livers of rats administered GEY/RES for 2 weeks, whereas CYP2E1 mRNA was suppressed. Postchallenge treatment with GEY/RES enhanced the alcohol clearance rate by lowering blood concentrations of alcohol and acetaldehyde by 24% and 26.6%, respectively, for the highest dose group. GEY/RES remarkably eliminated 2,2-diphenyl-1-picrylhydrazyl hydrate radical and FeCl3-mediated lipid peroxidation in vitro and attenuated hepatic lipid accumulation following ethanol administration in vivo. Therefore, it is suggested that GEY/RES reduces the blood concentrations of alcohol and acetaldehyde not only by modulating alcohol-metabolizing enzymes, but also by exerting its antioxidant activity, and that GEY/RES could be a promising candidate for improvements of alcoholic hangover. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Effects of a Preparation of Combined Glutathione-Enriched Yeast and Rice Embryo/Soybean Extracts on Ethanol Hangover | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/jmf.2008.1367 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.12, no.6, pp 1359 - 1367 | - |
dc.identifier.kciid | ART001413459 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000273180900027 | - |
dc.identifier.scopusid | 2-s2.0-74349115529 | - |
dc.citation.endPage | 1367 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1359 | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | alcohol hangover | - |
dc.subject.keywordAuthor | alcohol-metabolizing enzymes | - |
dc.subject.keywordAuthor | glutathione-enriched yeast | - |
dc.subject.keywordAuthor | rice embryo/soybean | - |
dc.subject.keywordPlus | ALCOHOL-DEHYDROGENASE ACTIVITY | - |
dc.subject.keywordPlus | TETRACHLORIDE-INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | CARBON-TETRACHLORIDE | - |
dc.subject.keywordPlus | THIAMINE-DEFICIENCY | - |
dc.subject.keywordPlus | LIVER-DAMAGE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | PHASE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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