Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase
DC Field | Value | Language |
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dc.contributor.author | Shin, Cha-Gyun | - |
dc.contributor.author | An, Dog-Gn | - |
dc.contributor.author | Song, Hyuk-Hwan | - |
dc.contributor.author | Lee, Chan | - |
dc.date.available | 2019-05-30T02:37:51Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0021-8820 | - |
dc.identifier.issn | 1881-1469 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22878 | - |
dc.description.abstract | Some enniatins (ENs) reportedly exhibit antiretroviral activities in vivo. The potential inhibitory activities of cyclic hexadepsipeptides such as beauvericin (BEA) and ENs H, I and MK1688 were investigated in vitro against human immunodeficiency virus type-1 (HIV-1) integrase and Moloney murine leukemia virus reverse transcriptase. BEA, EN I and EN MK1688 exhibited strong inhibitory activities against HIV-1 integrase, whereas EN H showed relatively weak activity. None of the examined compounds showed anti-reverse transcriptase activity. BEA was the most effective inhibitor of the tested cyclic hexadepsipepticles in inhibiting HIV-1 integrase. These results indicate the potential of cyclic hexadepsipeptides as a new class of potent inhibitors of HIV-1 integrase. The Journal of Antibiotics (2009) 62, 687-690; doi:10.1038/ja.2009.102; published online 6 November 2009 | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | JAPAN ANTIBIOTICS RESEARCH ASSOC | - |
dc.title | Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/ja.2009.102 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIBIOTICS, v.62, no.12, pp 687 - 690 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000273408800005 | - |
dc.identifier.scopusid | 2-s2.0-73649094425 | - |
dc.citation.endPage | 690 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 687 | - |
dc.citation.title | JOURNAL OF ANTIBIOTICS | - |
dc.citation.volume | 62 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | beauvericin | - |
dc.subject.keywordAuthor | enniatins | - |
dc.subject.keywordAuthor | HIV-1 | - |
dc.subject.keywordAuthor | inhibitor | - |
dc.subject.keywordAuthor | integrase | - |
dc.subject.keywordPlus | HIV-1 INTEGRASE | - |
dc.subject.keywordPlus | RETROVIRUS | - |
dc.subject.keywordPlus | MARINE | - |
dc.subject.keywordPlus | ESTER | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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