Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1
DC Field | Value | Language |
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dc.contributor.author | Lee, Hana | - |
dc.contributor.author | Chi, Seung Wook | - |
dc.contributor.author | Lee, Phil Young | - |
dc.contributor.author | Kang, Sunghyun | - |
dc.contributor.author | Cho, Sayeon | - |
dc.contributor.author | Lee, Chong-Kil | - |
dc.contributor.author | Bae, Kwang-Hee | - |
dc.contributor.author | Park, Byoung Chul | - |
dc.contributor.author | Park, Sung Goo | - |
dc.date.available | 2019-05-30T02:39:00Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22911 | - |
dc.description.abstract | Dihydroxyacetone (DHA) induces the formation of advanced glycation endproducts (AGEs), which are involved in several diseases. Earlier, we identified dihydroxyacetone kinase 1 (Dak1) as a candidate glutathione peroxidase 3 (Gpx3)-interacting protein in Saccharomyces cerevisiae. This finding is noteworthy, as no clear evidence on the involvement of oxidative stress systems in DHA-induced AGE formation has been found to date. Here, we demonstrate that Gpx3 interacts with Dak1, alleviates DHA-mediated stress by upregulating Dak activity, and consequently suppresses AGE formation. Based on these results, we propose that defense systems against oxidative stress and DHA-induced AGE formation are related via interactions between Gpx3 and Dak1. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.08.116 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.389, no.1, pp 177 - 180 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000274534900033 | - |
dc.identifier.scopusid | 2-s2.0-70349094844 | - |
dc.citation.endPage | 180 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 177 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 389 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Advanced glycation endproduct | - |
dc.subject.keywordAuthor | Dihydroxyacetone | - |
dc.subject.keywordAuthor | Dihydroxyacetone kinase 1 | - |
dc.subject.keywordAuthor | Glutathione peroxidase 3 | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | MAILLARD REACTION | - |
dc.subject.keywordPlus | END-PRODUCTS | - |
dc.subject.keywordPlus | GLUTATHIONE-PEROXIDASE-3 | - |
dc.subject.keywordPlus | DETOXIFICATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | AGES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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