The Influences of G Proteins, Ca2+ and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle
DC Field | Value | Language |
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dc.contributor.author | Park, Jun Hong | - |
dc.contributor.author | Kim, Hyun Sik | - |
dc.contributor.author | Park, Sun Young | - |
dc.contributor.author | Im, Chaeuk | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Kim, In Kyeom | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-05-30T02:41:08Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22970 | - |
dc.description.abstract | NO released by myenteric neurons controls the off contraction induced by electrical field stimulation (EFS) in distal esophageal smooth muscle, but in the presence of nitric oxide synthase (NOS) inbibitor, L-NAME, contraction by EFS occurs at the same time. The authors investigated the intracellular signaling pathways related with G protein and ionic channel EFS-induced contraction using cat esophageal muscles. EFS-induced contractions were significantly suppressed by tetrodotoxin (1 mu M) and atropine (1 mu M). Furthermore, nimodipine inhibited both on and off contractions by EFS in a concentration dependent meaner. The characteristics of 'on' and 'off' contraction and the effects of G-proteins, phospholipase, and K+ channel on EFS-induced contraction in smooth muscle were also investigated. Pertussis toxin (PTX, a G(i) inactivator) attenuated both EFS-induced contractions. Cholera toxin (CTX, G(s) inactivator) also decreased the amplitudes of EFS-induced off and on contractions. However, phospholipase inhibitors did not affect these contractions. Pinacidil (a K+ channel opener) decreased these contractions, and tetraethylammonium (TEA, K-Ca(+) channel blocker) increased them. These results suggest that EFS-induced on and off contractions ran be mediated by the activations Gi or Gs proteins, and that L-type Ca2+ channel may be activated by G-protein alpha subunits. Furthermore, K-Ca-(+) channel involve in the depolarization of esophageal smooth muscle. Further studies are required to characterize the physiological regulation of Ca2+ channel and to investigate the effects of other K+ channels on EFS-induced on and off contractions. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | The Influences of G Proteins, Ca2+ and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2009.13.5.393 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.13, no.5, pp 393 - 400 | - |
dc.identifier.kciid | ART001388700 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000271820200010 | - |
dc.identifier.scopusid | 2-s2.0-70450200071 | - |
dc.citation.endPage | 400 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 393 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | EFS | - |
dc.subject.keywordAuthor | Cat esophageal | - |
dc.subject.keywordAuthor | Circular smooth muscle | - |
dc.subject.keywordAuthor | NO | - |
dc.subject.keywordAuthor | L-type Ca2+ channel | - |
dc.subject.keywordPlus | INHIBITORY JUNCTION POTENTIALS | - |
dc.subject.keywordPlus | G-BETA-GAMMA | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | SPHINCTER RELAXATION | - |
dc.subject.keywordPlus | OPOSSUM ESOPHAGUS | - |
dc.subject.keywordPlus | CIRCULAR MUSCLE | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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