A 2.7-kb Deletion in the Human NLRP10 Gene Exon 2 Occurred After the Human-Chimpanzee Divergence
DC Field | Value | Language |
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dc.contributor.author | Ha, Hye Jeong | - |
dc.contributor.author | Kim, Dong Seon | - |
dc.contributor.author | Hahn, Yoonsoo | - |
dc.date.available | 2019-05-30T02:42:20Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 0006-2928 | - |
dc.identifier.issn | 1573-4927 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23001 | - |
dc.description.abstract | NLRP10 is a member of the NLRP protein family, which is involved in inflammation and apoptosis. Genome sequence comparisons revealed that a 2.7-kb deletion occurred in the human NLRP10 gene exon 2 after the divergence of humans and chimpanzees, resulting in replacement of the entire 3' untranslated region with the flanking LINE-1 element. The human NLRP10 protein lost 30 or more amino acids that are conserved in primates at its carboxy-terminus. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.title | A 2.7-kb Deletion in the Human NLRP10 Gene Exon 2 Occurred After the Human-Chimpanzee Divergence | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10528-009-9262-2 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL GENETICS, v.47, no.9-10, pp 665 - 670 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000269911300006 | - |
dc.identifier.scopusid | 2-s2.0-70349612325 | - |
dc.citation.endPage | 670 | - |
dc.citation.number | 9-10 | - |
dc.citation.startPage | 665 | - |
dc.citation.title | BIOCHEMICAL GENETICS | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Human | - |
dc.subject.keywordAuthor | Chimpanzee | - |
dc.subject.keywordAuthor | NLRP10 | - |
dc.subject.keywordAuthor | Molecular evolution | - |
dc.subject.keywordAuthor | LINE-1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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