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A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Min, Kyung Hoon | - |
| dc.contributor.author | Xia, Yan | - |
| dc.contributor.author | Kim, Eun Kyung | - |
| dc.contributor.author | Jin, Yinglan | - |
| dc.contributor.author | Kaur, Navneet | - |
| dc.contributor.author | Kim, Eun Seon | - |
| dc.contributor.author | Kim, Dae Kyong | - |
| dc.contributor.author | Jung, Hwa Young | - |
| dc.contributor.author | Choi, Yongseok | - |
| dc.contributor.author | Park, Mi-Kyung | - |
| dc.contributor.author | Min, Yong Ki | - |
| dc.contributor.author | Lee, Kiho | - |
| dc.contributor.author | Lee, Kyeong | - |
| dc.date.available | 2019-05-30T02:42:45Z | - |
| dc.date.issued | 2009-09 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23014 | - |
| dc.description.abstract | Novel disubstituted adamantyl derivatives were synthesized and evaluated in a P-glycoprotein dependent multidrug resistance cancer cell line. The hit to lead optimization provided potent MDR reversal agents. Some potent adamantyl derivatives were more than 10-fold more potent than verapamil without considerable intrinsic cytotoxicity. The 3-trifluorophenyl derivative 14f did not affect the metabolism of CYP450 3A4, whereas most of MDR revertants had a weak inhibitory effect. (C) 2009 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.bmcl.2009.07.127 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.18, pp 5376 - 5379 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.wosid | 000269760900020 | - |
| dc.identifier.scopusid | 2-s2.0-68949132702 | - |
| dc.citation.endPage | 5379 | - |
| dc.citation.number | 18 | - |
| dc.citation.startPage | 5376 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 19 | - |
| dc.type.docType | Article | - |
| dc.publisher.location | 영국 | - |
| dc.subject.keywordAuthor | Multidrug resistance | - |
| dc.subject.keywordAuthor | MES-SA/DX5 | - |
| dc.subject.keywordAuthor | ABC transporter | - |
| dc.subject.keywordAuthor | P-glycoprotein | - |
| dc.subject.keywordAuthor | Adamantane | - |
| dc.subject.keywordAuthor | CYP3A4 | - |
| dc.subject.keywordPlus | DRUG-RESISTANCE | - |
| dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
| dc.subject.keywordPlus | CANCER | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
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