Antioxidant Effect of CoQ(10) on N-nitrosodiethylamine-induced Oxidative Stress in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ho Sun | - |
dc.contributor.author | Kim, Hee Rae | - |
dc.contributor.author | Park, Tae Wook | - |
dc.contributor.author | Cho, Bong Jae | - |
dc.contributor.author | Choi, Mi Young | - |
dc.contributor.author | Kim, Chang Jong | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.contributor.author | Sim, Sang Soo | - |
dc.date.available | 2019-05-30T02:54:46Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23053 | - |
dc.description.abstract | The antioxidant effect of CoQ(10) on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ(10) and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ(10) groups. However, the increase of plasma aminotransferase activity was significantly reduced in the CoQ(10) group. Lipid peroxidation in various tissues, such as heart, lung, liver, kidney, spleen and plasma, was significantly increased by NDEA, but this increase was significantly reduced by 100 mg/kg of CoQ(10). Superoxide dismutase activity increased significantly upon NDEA-induced oxidative stress in both the control and CoQ(10) groups with the effect being less in the CoQ(10) group. Catalase activity decreased significantly in both the control and CoQ(10) groups treated with NDEA, again with the effect being less in the CoQ(10) group. The lesser effect on superoxide dismutase and catalase in the NDEA-treated CoQ(10) group is indicative of the protective effect CoQ(10). Thus, CoQ(10) can offer useful protection against NDEA-induced oxidative stress. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Antioxidant Effect of CoQ(10) on N-nitrosodiethylamine-induced Oxidative Stress in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2009.13.4.321 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.13, no.4, pp 321 - 326 | - |
dc.identifier.kciid | ART001373567 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000269737700009 | - |
dc.identifier.scopusid | 2-s2.0-70349404445 | - |
dc.citation.endPage | 326 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 321 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Catalase | - |
dc.subject.keywordAuthor | CoQ(10) | - |
dc.subject.keywordAuthor | Lipid peroxidation | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Superoxide dismutase | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | UBIQUINONE FUNCTION | - |
dc.subject.keywordPlus | MEDICAL ASPECTS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ERYTHROCYTES | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.