Atherosclerotic Progression Attenuates the Expression of Nogo-B in Autopsied Coronary Artery: Pathology and Virtual Histology Intravascular Ultrasound Analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Wang-Soo | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Hong, Soon-Auck | - |
dc.contributor.author | Lee, Tae-Jin | - |
dc.contributor.author | Park, Eon-Sub | - |
dc.contributor.author | Kim, Hyoung-Joong | - |
dc.contributor.author | Lee, Kwang Je | - |
dc.contributor.author | Kim, Tae Ho | - |
dc.contributor.author | Kim, Chee Jeong | - |
dc.contributor.author | Ryu, Wang Seong | - |
dc.date.available | 2019-05-30T02:55:00Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23058 | - |
dc.description.abstract | The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibro-atheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5 +/- 8.3 yr), 12 late FAs (42.6 +/- 16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4 +/- 11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8 +/- 6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P < 0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Atherosclerotic Progression Attenuates the Expression of Nogo-B in Autopsied Coronary Artery: Pathology and Virtual Histology Intravascular Ultrasound Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2009.24.4.596 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.4, pp 596 - 604 | - |
dc.identifier.kciid | ART001366236 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000268940300009 | - |
dc.identifier.scopusid | 2-s2.0-70350731154 | - |
dc.citation.endPage | 604 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 596 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Nogo Protein | - |
dc.subject.keywordAuthor | Ultrasonography, Interventional | - |
dc.subject.keywordAuthor | Autopsy | - |
dc.subject.keywordPlus | RADIOFREQUENCY DATA-ANALYSIS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | VULNERABLE PLAQUE | - |
dc.subject.keywordPlus | RUPTURE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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