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Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

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dc.contributor.authorLi, Fu-Nan-
dc.contributor.authorKim, Nam-Jung-
dc.contributor.authorPaek, Seung-Mann-
dc.contributor.authorKwon, Do-Yeon-
dc.contributor.authorMin, Kyung Hoon-
dc.contributor.authorJeong, Yeon-Su-
dc.contributor.authorKim, Sun-Young-
dc.contributor.authorPark, Young-Ho-
dc.contributor.authorKim, Hee-Doo-
dc.contributor.authorPark, Hyeung-Geun-
dc.contributor.authorSuh, Young-Ger-
dc.date.available2019-05-30T03:33:27Z-
dc.date.issued2009-05-
dc.identifier.issn0968-0896-
dc.identifier.issn1464-3391-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23183-
dc.description.abstractWe have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleDesign, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2009.04.010-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.17, no.10, pp 3557 - 3567-
dc.description.isOpenAccessN-
dc.identifier.wosid000265683800005-
dc.identifier.scopusid2-s2.0-65349151388-
dc.citation.endPage3567-
dc.citation.number10-
dc.citation.startPage3557-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume17-
dc.type.docTypeArticle-
dc.publisher.location영국-
dc.subject.keywordAuthorDiarylalkyl amides-
dc.subject.keywordAuthorTRPV1 antagonists-
dc.subject.keywordPlusVANILLOID RECEPTOR-1-
dc.subject.keywordPlusNEUROPATHIC PAIN-
dc.subject.keywordPlusCAPSAICIN CREAM-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCONVERSION-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusTHIOUREAS-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusCHANNEL-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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