Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists
DC Field | Value | Language |
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dc.contributor.author | Li, Fu-Nan | - |
dc.contributor.author | Kim, Nam-Jung | - |
dc.contributor.author | Paek, Seung-Mann | - |
dc.contributor.author | Kwon, Do-Yeon | - |
dc.contributor.author | Min, Kyung Hoon | - |
dc.contributor.author | Jeong, Yeon-Su | - |
dc.contributor.author | Kim, Sun-Young | - |
dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Kim, Hee-Doo | - |
dc.contributor.author | Park, Hyeung-Geun | - |
dc.contributor.author | Suh, Young-Ger | - |
dc.date.available | 2019-05-30T03:33:27Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23183 | - |
dc.description.abstract | We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bmc.2009.04.010 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.17, no.10, pp 3557 - 3567 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000265683800005 | - |
dc.identifier.scopusid | 2-s2.0-65349151388 | - |
dc.citation.endPage | 3567 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3557 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Diarylalkyl amides | - |
dc.subject.keywordAuthor | TRPV1 antagonists | - |
dc.subject.keywordPlus | VANILLOID RECEPTOR-1 | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | CAPSAICIN CREAM | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | THIOUREAS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | CHANNEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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