Association of Tumor Necrosis Factor-alpha with Fever and Pulmonary Lesion Score in Pigs Experimentally Infected with Swine Influenza Virus Subtype H1N2
DC Field | Value | Language |
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dc.contributor.author | Kim, Bongtae | - |
dc.contributor.author | Ahn, Kyoung Kyu | - |
dc.contributor.author | Ha, Yooncheol | - |
dc.contributor.author | Lee, Yong Hoon | - |
dc.contributor.author | Kim, Duyeol | - |
dc.contributor.author | Lim, Jeong Han | - |
dc.contributor.author | Kim, Sung-Hoon | - |
dc.contributor.author | Kim, Mi-Young | - |
dc.contributor.author | Cho, Kyung-Dong | - |
dc.contributor.author | Lee, Bog-Hieu | - |
dc.contributor.author | Chae, Chanhee | - |
dc.date.available | 2019-05-30T03:33:50Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.issn | 1347-7439 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23196 | - |
dc.description.abstract | The relationship between tumor necrosis factor (TNF)-alpha level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-alpha was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-alpha concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (P < 0.05) and steady thereafter. Mean rectal temperatures were above 40 degrees C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-alpha in BAL fluids from pigs experimentally infected with SIV (r(s)=0.9754, P < 0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF-alpha (r(s)=0.9949, P < 0.001). The results Suggest that the expression of TNF-alpha protein plays an important role in induction of pulmonary lesion and clinical Sign Such as fever in SIV infection. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | JAPAN SOC VET SCI | - |
dc.title | Association of Tumor Necrosis Factor-alpha with Fever and Pulmonary Lesion Score in Pigs Experimentally Infected with Swine Influenza Virus Subtype H1N2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1292/jvms.71.611 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, v.71, no.5, pp 611 - 616 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000266833100011 | - |
dc.identifier.scopusid | 2-s2.0-67650507344 | - |
dc.citation.endPage | 616 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 611 | - |
dc.citation.title | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.volume | 71 | - |
dc.type.docType | Article | - |
dc.publisher.location | 인도 | - |
dc.subject.keywordAuthor | fever | - |
dc.subject.keywordAuthor | H1N2 Subtype | - |
dc.subject.keywordAuthor | swine influenza Virus | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
dc.subject.keywordPlus | A VIRUS | - |
dc.subject.keywordPlus | CLINICAL-SAMPLES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | H3N2 VIRUSES | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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