Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation
DC Field | Value | Language |
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dc.contributor.author | Sul, Donggeun | - |
dc.contributor.author | Kim, Hyo-Shin | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Joo, Seong Soo | - |
dc.contributor.author | Hwang, Kwang Woo | - |
dc.contributor.author | Park, So-Young | - |
dc.date.available | 2019-05-30T03:37:47Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.issn | 1879-0631 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23309 | - |
dc.description.abstract | Aims: The progressive accumulation of beta-amyloid peptide (A beta), in the form of senile plaques, has been recognized as one of the major causes of Alzheimer's disease (AD) pathology. Increased production of A beta and the aggregation of A beta, to oligomers have been reported to trigger neurotoxicity, oxidative damage and inflammation. Furthermore, A beta-induced tau hyperphosphorylation and neurotoxicity are downstream of A beta. Therefore, we studied the possible neuroprotective effects of caffeic acid against A beta-induced toxicity. Main methods: Treatment of PC12 cells with 10 mu M A beta (25-35) for 24 h significantly decreased the cell viability; this was accompanied by an increase in intracellular calcium levels and tau phosphorylation with GSK-3 beta (glycogen synthase kinase-3 beta) activation (phosphorylation). Key findings: However, pretreatment of the PC12 cells with 10 and 20 mu g/ml of caffeic acid. for 1 h prior to A beta, significantly reversed the A beta-induced neurotoxicity by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Significance: Taken together, these results suggest that caffeic acid protected the PC12 cells against A beta-induced toxicity. In addition, the neuroprotective mechanisms of caffeic acid against A beta attenuated intracellular calcium influx and decreased tau phosphorylation by the reduction of GSK-3 beta activation. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.lfs.2008.12.001 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.84, no.9-10, pp 257 - 262 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000263662100001 | - |
dc.identifier.scopusid | 2-s2.0-59649111139 | - |
dc.citation.endPage | 262 | - |
dc.citation.number | 9-10 | - |
dc.citation.startPage | 257 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 84 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Caffeic acid | - |
dc.subject.keywordAuthor | Beta-amyloid | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Calcium influx | - |
dc.subject.keywordAuthor | Tau phosphorylation | - |
dc.subject.keywordAuthor | GSK-3 beta | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3-BETA | - |
dc.subject.keywordPlus | PAIRED HELICAL FILAMENTS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | HYPERPHOSPHORYLATED TAU | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTIES | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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