Effects of (-) epigallocatechin-3-gallate on Na+ currents in rat dorsal root ganglion neurons
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hoon | - |
dc.contributor.author | Lim, Jae-Min | - |
dc.contributor.author | Kim, Sung Sul | - |
dc.contributor.author | Kim, Jungho | - |
dc.contributor.author | Park, Mijung | - |
dc.contributor.author | Song, Jin-Ho | - |
dc.date.available | 2019-05-30T03:38:00Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23317 | - |
dc.description.abstract | The natural product(-) epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent found in green tea. Dorsal root ganglion neurons are primary sensory neurons, and express tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ currents, which are both actively involved in the generation and propagation of nociceptive signals. Effects of EGCG on tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ currents in rat dorsal root ganglion neurons were investigated using the whole-cell variation of the patch-clamp techniques. EGCG inhibited both types of Na+ currents potently and in a concentration-dependent manner. The apparent dissociation constant, K-d, was estimated to be 0.74 and 0.80 mu M for tetroclotoxin-sensitive and tetrodotoxin-resistant Na+ currents, respectively. (-) Epigallocatechin (EGC) was far less potent to inhibit Na+ currents than EGCG, suggesting that gallate moiety of EGCG is an important functional group to modulate Na+ currents. EGCG had little or no effect on the activation or steady-state inactivation voltage of either type of Na+ current. EGCG simply reduced the availability of Na+ channels for activation. Thus, EGCG appears to bind to resting Na+ channels to inhibit them. EGCG slowed the recovery of tetrodotoxin-sensitive Na+ current from inactivation. The property of EGCG to inhibit sensory Na+ currents can be utilized to develop an analgesic agent. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Effects of (-) epigallocatechin-3-gallate on Na+ currents in rat dorsal root ganglion neurons | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejphar.2008.12.015 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.604, no.1-3, pp 20 - 26 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000263756700003 | - |
dc.identifier.scopusid | 2-s2.0-58949100096 | - |
dc.citation.endPage | 26 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 20 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 604 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Catechins | - |
dc.subject.keywordAuthor | Dorsal root ganglion | - |
dc.subject.keywordAuthor | (-)Epigallocatechin-3-gallate | - |
dc.subject.keywordAuthor | Green tea | - |
dc.subject.keywordAuthor | Na+ current | - |
dc.subject.keywordAuthor | Tetrodotoxin-resistant | - |
dc.subject.keywordAuthor | Tetrodotoxin-sensitive | - |
dc.subject.keywordPlus | CHANNEL ALPHA-SUBUNIT | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | (-)-EPIGALLOCATECHIN GALLATE | - |
dc.subject.keywordPlus | SODIUM-CHANNELS | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | POTASSIUM CHANNELS | - |
dc.subject.keywordPlus | INFLAMMATORY PAIN | - |
dc.subject.keywordPlus | GABA(A) RECEPTORS | - |
dc.subject.keywordPlus | EGCG | - |
dc.subject.keywordPlus | POLYPHENOL | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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