The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock
DC Field | Value | Language |
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dc.contributor.author | Jeong, Young-Il | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Lee, Chang-Min | - |
dc.contributor.author | Chang, Jeong Hyun | - |
dc.contributor.author | Chun, Sung Hak | - |
dc.contributor.author | Noh, Kyung Tae | - |
dc.contributor.author | Jeong, Soo kyung | - |
dc.contributor.author | Shin, Yong Kyoo | - |
dc.contributor.author | Lee, Won Suk | - |
dc.contributor.author | Kang, Mi Sun | - |
dc.contributor.author | Lee, Sang-Yull | - |
dc.contributor.author | Lee, Jae-Dong | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.date.available | 2019-05-30T03:42:49Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23429 | - |
dc.description.abstract | Background: Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock. Principal Findings: In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Administration of PAF prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil infiltration, and severe multiple organ failure. In addition, PAF treatment protects against LPS-induced lymphocytes apoptosis. These protective effects of PAF was correlated with significantly decreases in the production of the inflammatory mediators such as TNF-α, IL-1β, IL-12, and IFN-γ, while increasing production of the anti-inflammatory cytokine IL-10 in vivo and in vitro. Conclusions: Taken together, these results suggest that PAF may protect mice against endotoxic shock via a complex mechanism involving modulation of inflammatory and anti-inflammatory mediators. © 2009 Jeong et al. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0006503 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.4, no.8 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000268637800013 | - |
dc.identifier.scopusid | 2-s2.0-68349154445 | - |
dc.citation.number | 8 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MEDIATOR | - |
dc.subject.keywordPlus | FAILURE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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