Calcium Hydroxide Inactivates Lipoteichoic Acid from Enterococcus faecalis
DC Field | Value | Language |
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dc.contributor.author | Baik, Jung Eun | - |
dc.contributor.author | Kum, Kee-Yeon | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Lee, Jin-Kyung | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Kim, Kack Kyun | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.date.available | 2019-05-30T04:37:07Z | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 0099-2399 | - |
dc.identifier.issn | 1878-3554 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23576 | - |
dc.description.abstract | Calcium hydroxide is a widely used endodontic medicament for eliminating viable bacteria and inactivating virulence factors. Enterococcus faecalis, a pathogenic gram-positive bacterium, has been associated with refractory apical periodontitis, Because lipoteichoic acid (LTA) is a major virulence factor of gram-positive bacteria, we examined whether calcium hydroxide could detoxify LTA from E. faecalis. An enzyme-linked immunosorbent assay showed that calcium hydroxide-killed E. faecalis was less potent than heat-killed bacteria in stimulating the release of tumor necrosis factor-a by a murine macrophage line, RAW 264.7 (P < 0.05). Pretreatment of LTA with calcium hydroxide remarkably abrogated the ability of LTA to induce the release of tumor necrosis factor-alpha (P < 0.05). Furthermore, calcium hydroxide-treated LTA was not able to stimulate Toll-like receptor 2, which recognizes functionally intact LTA. These results suggest that calcium hydroxide could detoxify LTA, resulting in attenuation of the inflammatory responses to E. faecalis and its LTA. (J Endod 2008;34:1355-1359) | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Calcium Hydroxide Inactivates Lipoteichoic Acid from Enterococcus faecalis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.joen.2008.08.014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENDODONTICS, v.34, no.11, pp 1355 - 1359 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000261021400012 | - |
dc.identifier.scopusid | 2-s2.0-53549112154 | - |
dc.citation.endPage | 1359 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1355 | - |
dc.citation.title | JOURNAL OF ENDODONTICS | - |
dc.citation.volume | 34 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Apical periodontitis | - |
dc.subject.keywordAuthor | calcium hydroxide | - |
dc.subject.keywordAuthor | endodontic medicament | - |
dc.subject.keywordAuthor | Enterococcus faecalis | - |
dc.subject.keywordAuthor | lipoteichoic acid | - |
dc.subject.keywordAuthor | Toll-like receptor 2 | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-2 | - |
dc.subject.keywordPlus | ROOT-FILLED TEETH | - |
dc.subject.keywordPlus | ENDODONTIC IRRIGANTS | - |
dc.subject.keywordPlus | BIOFILM FORMATION | - |
dc.subject.keywordPlus | DENTINAL TUBULES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | MICROORGANISMS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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