Microtubule-associated Protein 1B Light Chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells
DC Field | Value | Language |
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dc.contributor.author | Lee, So-Youn | - |
dc.contributor.author | Kim, Jung-Woong | - |
dc.contributor.author | Jeong, Mi-Hee | - |
dc.contributor.author | An, Joo-Hee | - |
dc.contributor.author | Jang, Sang-Min | - |
dc.contributor.author | Song, Ki-Hyun | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.date.available | 2019-05-30T04:39:50Z | - |
dc.date.issued | 2008-08 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23652 | - |
dc.description.abstract | The tumor suppressor and transcription factor p53 is a key modulator of cellular stress responses and can trigger apoptosis in many cell types, including neurons. In this study, we have shown that the Microtubule-Associated Protein 1B (MAP1B) light chain can interact with the tumor suppressor p53. We also demonstrate that both p53 and the MAP1B light chain (MAP1B-LC1) alter their localization from the cytoplasm to the nucleus when neuroblastoma cells, SH-SY5Y, are treated with doxorubicin. Additionally, we demonstrate that the MAP1B-LC1 negatively regulates p53-dependent transcriptional activity of a reporter construct driven by the p21 promoter. Consequently, MAP1B-LC1 binds to p53 and this interaction leads to the inhibition of doxorubicin-induced apoptosis in SH-SY5Y cells. Structured summary: MINT-6701342, MINT-6706444: MAP1B-LC (uniprotkb: P46821) and P53 (uniprotkb: P04637) colocalize (MI: 0403) by. uorescence microscopy (MI: 0416) MINT-6700861, MINT-6701791: P53 (uniprotkb: P04637) physically interacts (MI: 0218) with MAP1B-LC (uniprotkb: P46821) by anti bait coimmunoprecipitation (MI: 0006) MINT-6702266, MINT-6702529: P53 (uniprotkb: P04637) physically interacts (MI: 0218) with MAP1B-LC (uniprotkb: P46821) by anti tag coimmunoprecipitation (MI: 0007) (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Microtubule-associated Protein 1B Light Chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2008.07.021 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.582, no.19, pp 2826 - 2832 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000259123200002 | - |
dc.identifier.scopusid | 2-s2.0-48749103221 | - |
dc.citation.endPage | 2832 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 2826 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 582 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | MAP1B-LC1 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | neuroblastoma | - |
dc.subject.keywordPlus | MICROTUBULE-ASSOCIATED PROTEIN | - |
dc.subject.keywordPlus | 1B | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | VARIANT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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