Characterization of nuclear localization signals of the prototype foamy virus integrase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | An, Dog Gn | - |
dc.contributor.author | Hyun, Usok | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.date.available | 2019-05-30T04:41:44Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.issn | 1465-2099 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23700 | - |
dc.description.abstract | To analyse the potential karyophilic activity of prototype foamy viruses (PFVs), we expressed the PFV integrase (IN) and its mutants as fusion proteins with enhanced green fluorescence protein. The subcellular localization of the fusion proteins was investigated by fluorescence microscopy. The PFV IN was found to be karyophilic and targeted the fusion protein to the nucleus. Mutational analyses demonstrated that the PFV IN contains a potent but non-transferable nuclear localization signal (NLS) in its C-terminal domain and contains five arginine and lysine residues between amino acids 308 and 329 that are critical for its NLS function. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.title | Characterization of nuclear localization signals of the prototype foamy virus integrase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1099/vir.0.83689-0 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GENERAL VIROLOGY, v.89, no.7, pp 1680 - 1684 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000257554600015 | - |
dc.identifier.scopusid | 2-s2.0-48849100166 | - |
dc.citation.endPage | 1684 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1680 | - |
dc.citation.title | JOURNAL OF GENERAL VIROLOGY | - |
dc.citation.volume | 89 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | REVERSE TRANSCRIPTION | - |
dc.subject.keywordPlus | DNA INTEGRATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HIV-1 INFECTION | - |
dc.subject.keywordPlus | LEDGF/P75 | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | IMPORT | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.