Kynurenic acid attenuates MPP+-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway
DC Field | Value | Language |
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dc.contributor.author | Lee, Do Yeon | - |
dc.contributor.author | Lee, Kyu-Sun | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Noh, Yoo Hun | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Cho, Soo Hyun | - |
dc.contributor.author | Yoon, Ok Ja | - |
dc.contributor.author | Lee, Won Bok | - |
dc.contributor.author | Kim, Kyung Yong | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Kim, Sung Su | - |
dc.date.available | 2019-05-30T04:43:15Z | - |
dc.date.issued | 2008-06 | - |
dc.identifier.issn | 0171-9335 | - |
dc.identifier.issn | 1618-1298 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23739 | - |
dc.description.abstract | Kynurenic acid (KYNA), a tryptophan metabolite in the kynurenine pathway, is protective against various insults. However, the molecular mechanism of this protective effect has not been identified. In this study, we examined the protective effects of KYNA against 1-methyl-4-phenylpyridinium (MPP+), the best-characterized toxin inducing pathological changes resembling Parkinson's disease (PD), using SH-SY5Y and SK-N-SH human neuroblastoma cells. Pre-treatment of KYNA attenuated MPP+-induced neuronal cell death in SH-SY5Y and SK-N-SH cells. MPP+-induced cell death was preceded by increases in Bax expression and mitochondrial dysfunction, such as collapse of mitochondrial membrane potential (Delta Psi(m)), release of cytochrome c from mitochondria into the cytoplasm, and increases in caspase-9/-3 activities. KYNA effectively inhibited all of these mitochondrial apoptotic processes. Our results indicate that KYNA plays a protective role by down-regulating Bax expression and maintaining mitochondrial function in MPP+-induced neuronal cell death, and suggest that KYNA may have therapeutic potential in PD. (C) 2008 Elsevier GmbH. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG | - |
dc.title | Kynurenic acid attenuates MPP+-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejcb.2008.03.003 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CELL BIOLOGY, v.87, no.6, pp 389 - 397 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000257947200005 | - |
dc.identifier.scopusid | 2-s2.0-44549089063 | - |
dc.citation.endPage | 397 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 389 | - |
dc.citation.title | EUROPEAN JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 87 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | kynurenic acid (KYNA) | - |
dc.subject.keywordAuthor | 1-methyl-4-phenylpyridinium (MPP+) | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | mitochondrial dysfunction | - |
dc.subject.keywordAuthor | neuronal apoptosis | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | SH-SY5Y CELLS | - |
dc.subject.keywordPlus | 1-METHYL-4-PHENYLPYRIDINIUM | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | TRYPTOPHAN | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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