Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ki-Hyun | - |
dc.contributor.author | Lee, Jong-Chan | - |
dc.contributor.author | Lee, Jonghwi | - |
dc.date.available | 2019-05-30T05:33:16Z | - |
dc.date.issued | 2008-04 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.issn | 1616-5195 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23776 | - |
dc.description.abstract | Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/mabi.200700161 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.8, no.4, pp 339 - 346 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000255564200005 | - |
dc.identifier.scopusid | 2-s2.0-48849106621 | - |
dc.citation.endPage | 346 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 339 | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | drug-delivery systems | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | non-linear polymers | - |
dc.subject.keywordAuthor | particle size distribution | - |
dc.subject.keywordAuthor | water-soluble polymers | - |
dc.subject.keywordPlus | BLOCK POLYELECTROLYTE SOLUTIONS | - |
dc.subject.keywordPlus | SCORPION-LIKE MACROMOLECULES | - |
dc.subject.keywordPlus | POLY(ETHYLENE OXIDE) | - |
dc.subject.keywordPlus | COPOLYMER MICELLES | - |
dc.subject.keywordPlus | SIDE-GROUPS | - |
dc.subject.keywordPlus | BIOLOGICAL SIGNIFICANCE | - |
dc.subject.keywordPlus | CYLINDRICAL BRUSHES | - |
dc.subject.keywordPlus | GRAFT-COPOLYMERS | - |
dc.subject.keywordPlus | MICELLIZATION | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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