Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E-2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Kyu | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Choi, Sun Eun | - |
dc.contributor.author | Park, Kwan Hee | - |
dc.contributor.author | Choi, Hyung Kyun | - |
dc.contributor.author | Lee, Min Won | - |
dc.date.available | 2019-05-30T05:34:18Z | - |
dc.date.issued | 2008-04 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23802 | - |
dc.description.abstract | Chemical investigation of the 80% Me2CO extract from the seeds of Prunus tomentosa led to the isolation and identification of six flavonoids: kaempferol (1), kaempferol 3-O-alpha-L-rhamnopyranoside (2; afzelin), kaempferol 3-O-beta-D-(6-acetyl)-glucopyranosyl(1-->4)-alpha-L-rhamnopyranoside (3; multiflorin A), kaempferol 3-O-beta-D-glucopyranosyl(1-->4)-alpha-L-rhamnopyranoside (4; multiflorin B), quercetin 3-O-alpha-L-rhamnopyranoside (5; quercitrin), and quercetin 3-O-beta-D-glucopyranosyl (1-->4)-alpha-L-rhamnopyranoside (6; multinoside A). Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E-2 production in interferon-gamma (INF-gamma) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro (COX-2) of the isolated compounds were evaluated. Compounds 1, 5, and 6 exhibited potent anti-oxidative activity in the DPPH radical scavenging assay with IC50 values of 57.2, 59.4, and 54.3 mu g/mL respectively. The positive control, ascorbic acid, had an IC50 of 55.5 mu g/mL. Compounds 1, 5, and 6 also reduced COX-2 levels in a dose dependent manner with IC50 values of 10.2, 8.7, and 9.6 mu g/mL respectively, with the positive control, indomethacin, having an IC50 of 5.1 mu g/mL. All six compounds inhibited NO production in a dose dependent manner with IC50 values of 35.1, 42.8, 40.0, 44.8, 43.7, and 43.9 mu g/mL respectively, while the positive control, L-NMMA, had an IC50 of 42.1 mu g/mL. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E-2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-001-1174-9 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.31, no.4, pp 424 - 428 | - |
dc.identifier.kciid | ART001233158 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000255033000003 | - |
dc.identifier.scopusid | 2-s2.0-43049110584 | - |
dc.citation.endPage | 428 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 424 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 31 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Prunus tomentosa | - |
dc.subject.keywordAuthor | rosaceae | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordAuthor | antioxidative activity | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.