Prenatal increased asymmetric dimethylarginine is associated with placental heat-shock protein 70 and lectin-like oxidized low-density lipoprotein receptor-1 expression
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Ju | - |
dc.contributor.author | Jeon, Yeo Jin | - |
dc.contributor.author | Ahn, Young Mo | - |
dc.contributor.author | Lee, Hwa Young | - |
dc.contributor.author | Woo, So Yeon | - |
dc.contributor.author | Park, Hye Sook | - |
dc.contributor.author | Ha, Eun Hee | - |
dc.contributor.author | Pang, Myung Geol | - |
dc.date.available | 2019-05-30T05:39:38Z | - |
dc.date.issued | 2007-11 | - |
dc.identifier.issn | 0188-4409 | - |
dc.identifier.issn | 1873-5487 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23944 | - |
dc.description.abstract | Background. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction by reversibly blocking NO production from L-arginine. To elucidate the association of prenatal status of ADMA with placental heat-shock protein 70 (HSP70) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in normal full-term pregnancies, we evaluated the expression of placental HSP70 and LOX-1. Methods. Tissue samples of placentas obtained from 60 normal-term pregnancies were categorized into 30 cases with a lower level of prenatal ADMA (0.28 +/- 0.07 mu M) and 30 cases with a higher level of prenatal ADMA (1.31 +/- 0.44 mu M). We evaluated the placental expression of HSP70 and LOX-1 with Western blot analysis and immunohistochemistry and determined the correlation between HSP70 and LOX-1. Results. We found that prenatal increased ADMA is associated with increased placental HSP70 and LOX-1 expression. Conclusions. We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues. (c) 2007 IMSS. Published by Elsevier Inc. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Prenatal increased asymmetric dimethylarginine is associated with placental heat-shock protein 70 and lectin-like oxidized low-density lipoprotein receptor-1 expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.aremed.2007.05.005 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF MEDICAL RESEARCH, v.38, no.8, pp 839 - 845 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000250489400006 | - |
dc.identifier.scopusid | 2-s2.0-34848873808 | - |
dc.citation.endPage | 845 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 839 | - |
dc.citation.title | ARCHIVES OF MEDICAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | ADMA | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | HSP70 | - |
dc.subject.keywordAuthor | LOX-1 | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | placenta | - |
dc.subject.keywordPlus | HEAT-SHOCK PROTEINS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | PLASMA-CONCENTRATIONS | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | PREECLAMPSIA | - |
dc.subject.keywordPlus | ADMA | - |
dc.subject.keywordPlus | PREGNANCIES | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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