CAU Scholar

Detailed Information

Cited 15 time in webofscience Cited 0 time in scopus
Metadata Downloads

2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity

Full metadata record
DC Field Value Language
dc.contributor.authorBhattarai, Bharat Raj-
dc.contributor.authorShresthaa, Suja-
dc.contributor.authorHam, Seung Wook-
dc.contributor.authorKim, Kwang Rok-
dc.contributor.authorCheon, Hyae Gyeong-
dc.contributor.authorLee, Keun-Hyeung-
dc.contributor.authorCho, Hyeongjin-
dc.date.available2019-05-30T05:39:52Z-
dc.date.issued2007-10-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23951-
dc.description.abstract2-O-Carboxymethylpyrogallol derivatives (4-17) were synthesized, with their in vitro inhibitory activities against PTP1B and in vivo antihyperglycemic effects examined. Compound 14, the most potent among the series, showed a K-i value of 1.1 mu M against PTP1B, 7-fold lower than that against TC-PTP. When compound 14 was fed to a high-fat diet-induced diabetic mouse model, significant improvements were observed in both the fasting glucose level and glucose tolerance. (C) 2007 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.title2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2007.08.019-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.19, pp 5357 - 5360-
dc.description.isOpenAccessN-
dc.identifier.wosid000250041400013-
dc.identifier.scopusid2-s2.0-34548629701-
dc.citation.endPage5360-
dc.citation.number19-
dc.citation.startPage5357-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.type.docTypeArticle-
dc.publisher.location영국-
dc.subject.keywordAuthor2-O-carboxymethylpyrogallol-
dc.subject.keywordAuthorPTP1B inhibitor-
dc.subject.keywordAuthordiabetes-
dc.subject.keywordAuthorglucose tolerance-
dc.subject.keywordAuthorhyperglycemia-
dc.subject.keywordAuthorprotein tyrosine phosphatase-
dc.subject.keywordPlusTYROSINE-PHOSPHATASE 1B-
dc.subject.keywordPlusINSULIN SENSITIVITY-
dc.subject.keywordPlusSELECTIVE INHIBITOR-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusERTIPROTAFIB-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusGLUCOSE-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusTCPTP-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Natural Sciences > Department of Chemistry > 1. Journal Articles
Show simple item record

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Ham, Seung Wook photo

Ham, Seung Wook
자연과학대학 (화학과)
Read more

Altmetrics

Total Views & Downloads

STATISTICS
Total View :7,497,882
Today View :8,684

RSS_1.0 RSS_2.0 ATOM_1.0

CONTACT US

84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194

COPYRIGHT 2019 Chung-Ang University All Rights Reserved.

Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.

BROWSE

한국어