Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Uk | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.contributor.author | Lee, Chong-Kyo | - |
dc.contributor.author | Lee, Yong Sup | - |
dc.date.available | 2019-05-30T05:40:42Z | - |
dc.date.issued | 2007-10 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.issn | 1768-3254 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23975 | - |
dc.description.abstract | Human immunodeficiency virus (HIV) integrase (IN) catalyzes the integration of HIV DNA copy into the host cell DNA. L-Chicoric acid (1) has been found to be one of the most potent HIV-1 integrase inhibitor. Caffeoylglycolic and caffeoylamino acid derivatives' halfmeric structures Of L-chicoric acid 2 were synthesized for the purpose of simplifying the structure Of L-Chicoric acid. Among synthesized, compounds 2c and 3f showed HIV-1 IN inhibitory activities with IC50 values of 10.5 and 12.0 mu M, respectively, comparable to that of parent compound L-chicoric acid (IC50 = 15.7 mu M). (c) 2007 Elsevier Masson SAS. All fights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejmech.2007.02.016 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.42, no.10, pp 1309 - 1315 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000250974600009 | - |
dc.identifier.scopusid | 2-s2.0-35248875223 | - |
dc.citation.endPage | 1315 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1309 | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 프랑스 | - |
dc.subject.keywordAuthor | human immunodeficiency virus | - |
dc.subject.keywordAuthor | integrase inhibitor | - |
dc.subject.keywordAuthor | L-chicoric acid | - |
dc.subject.keywordAuthor | caffcoylglycolic acid | - |
dc.subject.keywordAuthor | caffeoylamino acid | - |
dc.subject.keywordPlus | VIRUS TYPE-1 INTEGRASE | - |
dc.subject.keywordPlus | DICAFFEOYLTARTARIC ACIDS | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | ESTERS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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