Synthesis and HIV-1 integrase inhibitory activities of 4-hydroxy-5-azacoumarin 3-carboxamides
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Uk | - |
dc.contributor.author | Park, Jang Hyun | - |
dc.contributor.author | Kwon, Tae Hoon | - |
dc.contributor.author | Yoo, Yeong Jae | - |
dc.contributor.author | Lee, Jae Yeol | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.contributor.author | Yoo, Kyung Ho | - |
dc.contributor.author | Lee, Yong Sup | - |
dc.date.available | 2019-05-30T05:41:03Z | - |
dc.date.issued | 2007-09 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23984 | - |
dc.description.abstract | Recently, it has been reported that the inhibition of the strand transfer function of HIV-1 integrase is necessary to obtain significant antiviral activity. Accordingly, several compounds typified by aryl 1,3-diketo acids that can inhibit strand transfer reaction of HIV-1 IN have been identified. In this work, we synthesized new 4-hydroxy-5-azacoumarin-3-carbox(thio)amides (1a-h) and evaluated for the inhibition of HIV-1 IN strand transfer reaction with a brief SAR. Among synthesized, compound 1e was the most potent HIV-1 IN inhibitor with equipotent activity to that of L-708,906. Therefore, the 4-hydroxy-5-azacoumarin ring can be considered as a new scaffold in designing more potent of HIV-1 IN inhibitors for treatment of AIDS. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Synthesis and HIV-1 integrase inhibitory activities of 4-hydroxy-5-azacoumarin 3-carboxamides | - |
dc.type | Article | - |
dc.identifier.doi | 10.5012/bkcs.2007.28.9.1510 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.28, no.9, pp 1510 - 1514 | - |
dc.identifier.kciid | ART001074130 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000251301400011 | - |
dc.identifier.scopusid | 2-s2.0-34848834804 | - |
dc.citation.endPage | 1514 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1510 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | HIV-1 integrase inhibitor | - |
dc.subject.keywordAuthor | strand transfer | - |
dc.subject.keywordAuthor | 4-hydroxy-5-azacoumarin | - |
dc.subject.keywordPlus | IMMUNODEFICIENCY-VIRUS TYPE-1 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.