Nanoscopic friction behavior of pharmaceutical materials
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jonghwi | - |
dc.date.available | 2019-05-30T05:41:59Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24011 | - |
dc.description.abstract | The characteristics of various pharmaceutical dosage forms are influenced by surface properties such as the friction behavior. For example, die wall friction is a key issue in developing a solid dosage form. However, the friction properties are not completely understood mainly because of the lack of fundamental measurements. Herein, the friction behavior of pharmaceutical materials was investigated and compared with their adhesion behavior using atomic force microscopy. The sliding speed causes significant variations in the frictional force. Compared with other materials, lubricant materials showed less distinct differences in friction tests than in adhesion tests, indicating the dependence of the lubricant efficiency on the stress state. The three parameters obtained from the modified Amonton's law, i.e., absolute frictional force, friction coefficient and residual force, showed consistent trends. Overall, the friction behavior was not a direct reflection of the adhesion forces. The intrinsic friction behavior of a single pharmaceutical particle can be quantified using atomic force microscopy. (c) 2007 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Nanoscopic friction behavior of pharmaceutical materials | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2007.03.017 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.340, no.1-2, pp 191 - 197 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000248901800025 | - |
dc.identifier.scopusid | 2-s2.0-34447270779 | - |
dc.citation.endPage | 197 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 191 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 340 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | atomic force microscopy (AFM) | - |
dc.subject.keywordAuthor | adhesion | - |
dc.subject.keywordAuthor | flowability | - |
dc.subject.keywordAuthor | acetaminophen | - |
dc.subject.keywordPlus | ATOMIC-FORCE MICROSCOPY | - |
dc.subject.keywordPlus | ADHESION PROPERTIES | - |
dc.subject.keywordPlus | THIN-FILMS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | HUMIDITY | - |
dc.subject.keywordPlus | POWDERS | - |
dc.subject.keywordPlus | DISTRIBUTIONS | - |
dc.subject.keywordPlus | CANTILEVERS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.