NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling
DC Field | Value | Language |
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dc.contributor.author | Kang, Yeongsup | - |
dc.contributor.author | Lee, Deug-Chan | - |
dc.contributor.author | Han, Jiyou | - |
dc.contributor.author | Yoon, Seongmin | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Yeom, Ji-Hyun | - |
dc.contributor.author | Seong, Maeng-Je | - |
dc.contributor.author | Ko, Jeong-Jae | - |
dc.contributor.author | Lee, Kyung-Ah | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.date.available | 2019-05-30T05:42:45Z | - |
dc.date.issued | 2007-07 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24031 | - |
dc.description.abstract | The Bcl-2 family members are evolutionally conserved and crucial regulators of apoptosis. Diva (Boo), an ortholog of Bcl2L10 or Bcl-B, is a member of the Bcl-2 family that has contradictory functions in apoptosis. To understand the signaling mechanisms of Diva, we searched for proteins that interact with Diva using the yeast two-hybrid system. We identified a nucleoside diphosphate kinase isoform, NM23-H2. Here, we show that Diva bound to NM23-H2 in cells in which the transmembrane domain of Diva was required, and both proteins were colocalized in cytoplasm. Of interest, Diva protein level was significantly down-regulated by NM23-H2 as knock down of NM23-H2 restored Diva expression. Overexpression of NM23-H2 induced apoptosis, and the depletion of NM23-H2 led to the increase of Diva's apoptotic activity. Thus, these results indicate the existence of a previously undiscovered mechanism by which NM23-H2 involves in the regulation of Diva-mediated apoptosis. (C) 2007 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.05.090 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.359, no.1, pp 76 - 82 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000247257600013 | - |
dc.identifier.scopusid | 2-s2.0-34249725600 | - |
dc.citation.endPage | 82 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 76 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 359 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Diva | - |
dc.subject.keywordAuthor | Bcl2L10 | - |
dc.subject.keywordAuthor | Boo | - |
dc.subject.keywordAuthor | Bcl-B | - |
dc.subject.keywordAuthor | NM23-H2 | - |
dc.subject.keywordAuthor | NME | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | BCL-2 FAMILY | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | APAF-1 | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | BINDS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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