Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses
DC Field | Value | Language |
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dc.contributor.author | Lee, Yong Gyu | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Lee, Ji Yeon | - |
dc.contributor.author | Byeon, Se Eun | - |
dc.contributor.author | Hong, Eock Kee | - |
dc.contributor.author | Lee, Jaehwi | - |
dc.contributor.author | Rhee, Man Hee | - |
dc.contributor.author | Park, Hwa Jin | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.available | 2019-05-30T06:33:00Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24074 | - |
dc.description.abstract | Codonopsis lanceolata L. has long been used as a folk medicine in Korea, Japan and China for the treatment of lung inflammatory diseases. In this study, therefore, we aimed to demonstrate its ethnopharmacological activity by examining macrophage-function regulating effects. The total methanol extracts of fresh leaves (l-TME) or roots (r-TME) of Codonopsis lanceolata L. significantly suppressed the production of proinflammatory mediators (nitric oxide [NO] and tumor necrosis factor [TNF-alpha]) without altering mRNA levels. The expression of interleukin (IL)-3 and IL-6, however, was strongly diminished. According to the analysis of signaling enzyme activation by immunoblotting, phospho-I kappa B levels, a representative pro-inflammatory gene activation pathway, were not affected by the TMEs. By contrast, the Raf-ERK signaling pathway, which was involved in regulation of post-translational modification of pro-inflammatory gene products, was strongly blocked after 6-h of exposure. Moreover, l-TME down-regulated LPS-mediated phagocytic uptake and CD29-mediated cell-cell adhesion, while r-TME strongly up-regulated these two cellular events as well as fibronectin-cell adhesion. The surface levels of the costimulatory molecules (CD80 and CD86) of RAW264.7 cells were also enhanced by these extracts. l-TME also diminished functional activation (assessed by NO production) and the surface level of dectin-1, but not toll-like receptor (TLR)-2. Taken together, these data suggest that Codonopsis lanceolata may have the ability to modulate macrophage-mediated immune responses, thus contributing to its anti-inflammatory activity. (C) 2007 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jep.2007.02.026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.112, no.1, pp 180 - 188 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000247131100027 | - |
dc.identifier.scopusid | 2-s2.0-34247891436 | - |
dc.citation.endPage | 188 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 180 | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 112 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Codonopsis lanceolata | - |
dc.subject.keywordAuthor | campanulaceae | - |
dc.subject.keywordAuthor | immunomodulatory effect | - |
dc.subject.keywordAuthor | macrophage functions | - |
dc.subject.keywordPlus | ALPHA-CONVERTING ENZYME | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | KAPPA-B PATHWAY | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONE | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | HOMOTYPIC AGGREGATION | - |
dc.subject.keywordPlus | POTENTIAL ROLE | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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