The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test
DC Field | Value | Language |
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dc.contributor.author | Choi, Kwon | - |
dc.contributor.author | Lee, Seung Sei | - |
dc.contributor.author | Oh, Suk Joong | - |
dc.contributor.author | Lim, Seong Yong | - |
dc.contributor.author | Lim, Si Young | - |
dc.contributor.author | Jeon, Woo Kyu | - |
dc.contributor.author | Oh, Tae Yun | - |
dc.contributor.author | Kim, Jeong Wook | - |
dc.date.available | 2019-05-30T06:36:09Z | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.issn | 1532-1983 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24167 | - |
dc.description.abstract | Background Et aims: Systemic chemotherapy may damage gastrointestinal epithelium. Mucositis is associated with increased intestinal permeability (IP). It is known that IP test with chromium 51-ethylene diaminetetra-acetate (Cr-51-EDTA) is a useful tool to assess the mucositis. Oral glutamine supplements (OGS) may have a role in the prevention of chemotherapy-induced mucositis/stomatitis. The aim of this study was to characterize the relationship between the urinary excretion of Cr-51-EDTA and the severity of mucositis, and the effect of OGS on 5-fluorouracil/leucovorin (FU/LV)-induced mucositis/stomatitis. Methods: Fifty-one patients with advanced or metastatic cancer received FU/LV chemotherapy. The control. group included 18 healthy volunteers. IP was assessed via the measurement of Cr-51-EDTA urinary excretion after oral challenge, on days 7 after the discontinuation of chemotherapy. Of the 51 patients, 22 patients received OGS (30 g/day) and 29 received only best supportive care (BSC). Glutamine supplementation continued for 15 days. It was initiated at least 3 days before the beginning of chemotherapy. Mucositis/ stomatitis was graded according to version 3.0 of the Common Terminology Criteria for Adverse Events. Results: In the chemotherapy group, the median (25 percentile, 75 percentile) IP test score was significantly higher than those of the control group [6.78% (4.63, 10.66) vs. 2.17% (1.38, 2.40), P < 0.001]. The severity of stomatitis was significantly correlated with IP test scores (r = 0.898, P < 0.001). In the OGS group, the median IP test score was significantly lower than that of the BSC group [4.69% (3.10, 6.48) vs. 8.54% (6.48, 15.31), P < 0.001]. A mucositis/stomatitis of grade 2-4 was observed in two patients of the OGS group (9%), and in 11 patients (38%) in the BSC group (P < 0.001). Conclusions: The IP test may be a useful tool. in the evaluation of mucositis/stornatitis. OGS may exert a protective effect on FU/LV-induced mucositis/stomatitis. Further studies, however, will be necessary to define the role of glutamine supplementation in FU/LV-induced mucositis/stomatitis. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.title | The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.clnu.2006.07.003 | - |
dc.identifier.bibliographicCitation | CLINICAL NUTRITION, v.26, no.1, pp 57 - 62 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000245330000008 | - |
dc.identifier.scopusid | 2-s2.0-33846610988 | - |
dc.citation.endPage | 62 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 57 | - |
dc.citation.title | CLINICAL NUTRITION | - |
dc.citation.volume | 26 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스코트랜드 | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | intestinal permeability | - |
dc.subject.keywordAuthor | glutamine | - |
dc.subject.keywordAuthor | mucositis | - |
dc.subject.keywordAuthor | stomatitis | - |
dc.subject.keywordPlus | INDUCED STOMATITIS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordPlus | MUCOSITIS | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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