An evaluation of the neonatal immune system using a Listeria infection model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Hyun-Jung | - |
dc.contributor.author | Jung, Woon-Won | - |
dc.contributor.author | Lee, Jong-Bae | - |
dc.contributor.author | Chung, Hee Yong | - |
dc.contributor.author | Sul, Donggeun | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Choi, Inho | - |
dc.contributor.author | Hwang, Kwang Woo | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.available | 2019-05-30T06:37:26Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.issn | 1661-7800 | - |
dc.identifier.issn | 1661-7819 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24205 | - |
dc.description.abstract | Background: T helper 1 (Th1)/T helper 2 (Th2)- biased cytokine regulation may be another reason that neonates are much more susceptible to infectious disease than are adults. Objectives: We attempted to determine the ability of neonatal mice to direct the Th1 phenotype against Listeria monocytogenes (LM), because LM, an intracellular Gram-positive bacterium, induces profound cellular immunity by Th1 cells in vivo. Methods: In order to determine whether neonatal mice evidence strong Th1 activity during LM infection, neonatal mice were compared with adult mice with regard to susceptibility to LM, cytotoxic T lymphocyte activity, and cytokine profiles. Neonatal gene profiles relevant to Th1 and Th2 differentiation during LM infection were also compared between neonatal and adult mice, via real-time PCR and RTPCR. Results: Neonatal mice were found to be far more susceptible to LM infection than adult mice, due to a lack in the induction of cytotoxic T cell activity, coupled with poor IFN-gamma secretion. Further, LM-infected neonatal mice evidenced much lower levels of expression of Th1-type immune components, including IL-12, IFN- gamma, Delta-4 and T-bet, as compared to those features in adult mice. These results may be due to the comparably lower expressions of mannose-bind lectins and some of toll-like receptors (TLRs) such as TLR-5, - 6 and - 9, necessary mediators to develop Th1 immune responses. Conclusions: Neonatal mice may not mount an adequate Th1 type immune response due to a significantly lower expression of Th1-type immune components as compared to adult mice, even when forced into a Th1-prone environment. Copyright (c) 2007 S. Karger AG, Basel. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | An evaluation of the neonatal immune system using a Listeria infection model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000100806 | - |
dc.identifier.bibliographicCitation | NEONATOLOGY, v.92, no.2, pp 83 - 90 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000248655900002 | - |
dc.identifier.scopusid | 2-s2.0-34547788269 | - |
dc.citation.endPage | 90 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | NEONATOLOGY | - |
dc.citation.volume | 92 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | neonate | - |
dc.subject.keywordAuthor | Listeria infection | - |
dc.subject.keywordAuthor | T helper 1 and T helper 2 imbalance | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | NEWBORNS | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.