Effects of L-norgestrel on the endothelium-dependent relaxation response of rabbit clitoral cavernous smooth muscles
- Authors
- Myung, Soon Chul; Kim, Sae-Chul; Lee, Shin Young; Han, Ji Yup; Lee, Moo Yeol
- Issue Date
- Oct-2006
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- L-norgestrel; clitoris; nitric oxide; potassium channel
- Citation
- FERTILITY AND STERILITY, v.86, no.4 SUPPL., pp 1170 - 1174
- Pages
- 5
- Journal Title
- FERTILITY AND STERILITY
- Volume
- 86
- Number
- 4 SUPPL.
- Start Page
- 1170
- End Page
- 1174
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24271
- DOI
- 10.1016/j.fertnstert.2005.12.080
- ISSN
- 0015-0282
1556-5653
- Abstract
- Objective: To determine the effect of a popular oral contraceptive, L-norgestrel (a synthetic progestogen), on relaxing response of clitoral cavernous smooth muscles. Design: Prospective, randomized study. Setting: Academic facility. Animal(s): Thirty adult female New Zealand White rabbits. Intervention(s): We conducted isometric tension studies with norepinephrine, endothelium-dependent (acetylcholine) and endothelium-independent (sodium nitroprusside), vasodilators, and L-norgestrel. The effects of nonspecific nitric oxide synthase inhibitor (N-w-nitro-L-arginine methyl ester) and the potassium channel blockers (1 and 10 mM tetraethylammonium as well as 10 mu M glibenclamide) on the reactivities of clitoral cavernous strips were investigated. Main Outcome Measure(s): Causation and power of developed tension after treatment. Result(s): Acetylcholine, sodium nitroprusside, and L-norgestrel produced concentration-dependent relaxation of the norepinephrine-precontracted strips. Both endothelium removal and treatment with 10 mu M N-w-nitro-L-arginine methyl ester completely inhibited the relaxation response to acetlycholine and L-norgestrel, and supplementation with 10 mM L-arginine partially reversed the inhibition. Incubation with either tetraethylammonium (TEA) or glibenclamide reduced the L-norgestrel-induced relaxation in a dose-independent manner. Conclusion(s): The L-norgestrel-induced relaxation of the clitoral cavernous smooth muscle is endothelium and nitric oxide dependent and may be related to more than two types of potassium channels activation.
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