Anti-inflammatory action of phenolic compounds from Gastrodia elata root
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Yun | - |
dc.contributor.author | Jang, Young Woon | - |
dc.contributor.author | Kang, Hyo Sook | - |
dc.contributor.author | Moon, Hee | - |
dc.contributor.author | Sim, Sang Soo | - |
dc.contributor.author | Kim, Chang Jong | - |
dc.date.available | 2019-05-30T06:39:39Z | - |
dc.date.issued | 2006-10 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24275 | - |
dc.description.abstract | Previous screening of the pharmacological action of Gastrodia elata (GE) root (Orchidaceae) showed that methanol (MeOH) extracts have significant anti-inflammatory properties. The anti-inflammatory agents of GE, however, remain unclear. In this experiment, MeOH extracts of GE were fractionated with organic solvents for the anti-inflammatory activity-guided separation of GE. Eight phenolic compounds from the ether (EtOEt) and ethyl acetate (EtOAc) fractions were isolated by column chromatography: 4-hydroxybenzaldehyde (1), 4-hydroxybenzyl alcohol (II), benzyl alcohol (III), bis-(4-hydroxyphenyl) methane (IV), 4(4'-hydroxybenzyloxy)benzyl methylether (V), 4-hydroxy-3-methoxybenzyl alcohol (VI), 4-hydroxy-3-methoxybenzaldehyde (VII), and 4-hydroxy-3-methoxybenzoic acid (VIII). To investigate the anti-inflammatory and anti-oxidant activity of these compounds, their effects on carrageenan-induced paw edema, arachidonic acid (AA)-induced ear edema and analgesic activity in acetic acid (HAc)-induced writhing response were carried out in vivo, cyclooxygenase (COX) activity, reactive oxygen species (ROS) generation in rat basophilic leukemia (RBL 2H3) cells and 1, 1-diphenyl-2-picryl-hydroazyl (DPPH) scavenging activity were determined in vitro. These phenolic compounds not only had anti-inflammatory and analgesic properties in vivo, but also inhibited COX activity and silica-induced ROS generation in a dose-dependent manner. Among these phenolic compounds, compound VII was the most potent anti-inflammatory and analgesic. Compound VII significantly inhibited silica-induced ROS generation and compound VI significantly increased DPPH radical scavenging activity. Compounds 1, 11 and III significantly inhibited the activity of COX-I and II. These results indicate that phenolic compounds of GE are anti-inflammatory, which may be related to inhibition of COX activity and to anti-oxidant activity. Consideration of the structure-activity relationship of the phenolic derivatives from GE on the anti-inflammatory action revealed that both C-4 hydroxy and C-3 methoxy radicals of benzyl alclehyde play an important role in anti-inflammatory activities. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Anti-inflammatory action of phenolic compounds from Gastrodia elata root | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/BF02973905 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.29, no.10, pp 849 - 858 | - |
dc.identifier.kciid | ART001087021 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000241675200007 | - |
dc.identifier.scopusid | 2-s2.0-33751336571 | - |
dc.citation.endPage | 858 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 849 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Gastrodia elata | - |
dc.subject.keywordAuthor | phenolic compounds | - |
dc.subject.keywordAuthor | anti-inflammatory activity | - |
dc.subject.keywordAuthor | anti-oxidant activity | - |
dc.subject.keywordPlus | P-HYDROXYBENZYL ALCOHOL | - |
dc.subject.keywordPlus | ARACHIDONIC-ACID | - |
dc.subject.keywordPlus | EAR EDEMA | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | PEROXIDATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | BLUME | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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