Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice - A role for manganese superoxide dismutase
DC Field | Value | Language |
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dc.contributor.author | Kim, Jinu | - |
dc.contributor.author | Kil, In Sup | - |
dc.contributor.author | Seok, Young Mi | - |
dc.contributor.author | Yang, Eun Sun | - |
dc.contributor.author | Kim, Dae Kyong | - |
dc.contributor.author | Lim, Dong Gun | - |
dc.contributor.author | Park, Jeen-Woo | - |
dc.contributor.author | Bonventre, Joseph V. | - |
dc.contributor.author | Park, Kwon Moo | - |
dc.date.available | 2019-05-30T06:40:29Z | - |
dc.date.issued | 2006-07-21 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24306 | - |
dc.description.abstract | Males are much more susceptible to ischemia/reperfusion (I/R)-induced kidney injury when compared with females. Recently we reported that the presence of testosterone, rather than the absence of estrogen, plays a critical role in gender differences in kidney susceptibility to I/R injury in mice. Although reactive oxygen species and antioxidant defenses have been implicated in I/R injury, their roles remain to be defined. Here we report that the orchiectomized animal had significantly less lipid peroxidation and lower hydrogen peroxide levels in the kidney 4 and 24 h after 30 min of bilateral renal ischemia when compared with intact or dihydrotestosterone-treated orchiectomized males. The post-ischemic kidney expression and activity of manganese superoxide dismutase (MnSOD) in orchiectomized mice was much greater than in intact or dihydrotestosterone-administered orchiectomized mice. Four hours after 30 min of bilateral ischemia, superoxide formation was significantly lower in orchiectomized mice than in intact mice. In Madin-Darby canine kidney cells, a kidney epithelial cell line, 1 mM H2O2 decreased MnSOD activity, an effect that was potentiated by pretreatment with dihydrotestosterone. Orchiectomy prevented the post-ischemic decrease of catalase activity. Treatment of male mice with manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin (MnTMPyP), a SOD mimetic, reduced the post-ischemic increase of plasma creatinine, lipid peroxidation, and tissue hydrogen peroxide. These results suggest that orchiectomy accelerates the post-ischemic activation of MnSOD and reduces reactive oxygen species and lipid peroxidation, resulting in reduced kidney susceptibility to I/R injury. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice - A role for manganese superoxide dismutase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1074/jbc.M512740200 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.281, no.29, pp 20349 - 20356 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000239038200059 | - |
dc.identifier.scopusid | 2-s2.0-33746018655 | - |
dc.citation.endPage | 20356 | - |
dc.citation.number | 29 | - |
dc.citation.startPage | 20349 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 281 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | INDUCED FUNCTIONAL INJURY | - |
dc.subject.keywordPlus | MAPK KINASE ACTIVATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTION | - |
dc.subject.keywordPlus | CHRONIC REJECTION | - |
dc.subject.keywordPlus | RENAL ISCHEMIA | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | GENDER | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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