Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection
DC Field | Value | Language |
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dc.contributor.author | Um, SY | - |
dc.contributor.author | Jung, SH | - |
dc.contributor.author | Jung, SJ | - |
dc.contributor.author | Kim, JI | - |
dc.contributor.author | Chung, SY | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Han, SB | - |
dc.contributor.author | Choi, SO | - |
dc.date.available | 2019-05-30T06:40:58Z | - |
dc.date.issued | 2006-06 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.issn | 1873-264X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24325 | - |
dc.description.abstract | A column-switching high-performance liquid chromatographic (HPLC) method has been developed and validated for quantification of fluvastatin in rat plasma. Plasma samples were diluted with an equal volume of mobile phase, i.e. acetonitrile-5 mM potassium phosphate buffer (pH 6.8) (15:85, v/v), and the mixture was directly injected onto the HPLC system. The analyte was enriched in a pre-treatment column, while endogenous components were eluted to waste. The analyte was then back-flushed onto an analytical column and quantified with fluorescence detection (lambda(ex) = 305 nm; lambda(em) = 390 nm). The standard curve for the drug was linear in the range 0.5-100 ng mL(-1) in rat plasma. The limit of quantitation for plasma was found to be 0.5 ng mL(-1). This method has been fully validated and shown to be specific, accurate and precise. The method is simple and rapid because of a minimized sample preparation and appears to be useful for the pharmacokinetic study of fluvastatin. (c) 2006 Published by Elsevier B.V. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jpba.2006.03.021 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v.41, no.4, pp 1458 - 1462 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000238491100059 | - |
dc.identifier.scopusid | 2-s2.0-33646915183 | - |
dc.citation.endPage | 1462 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1458 | - |
dc.citation.title | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | fluvastatin | - |
dc.subject.keywordAuthor | column-switching | - |
dc.subject.keywordAuthor | high-performance liquid chromatography (HPLC) | - |
dc.subject.keywordAuthor | rat plasma | - |
dc.subject.keywordAuthor | direct injection | - |
dc.subject.keywordPlus | COA REDUCTASE INHIBITORS | - |
dc.subject.keywordPlus | SAMPLE CLEANUP | - |
dc.subject.keywordPlus | URINE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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