Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Chan, Kum | - |
dc.contributor.author | Choi, Hee Jung | - |
dc.contributor.author | Park, Eon Sub | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-05-30T07:33:35Z | - |
dc.date.issued | 2006-02 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.issn | 1879-0631 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24406 | - |
dc.description.abstract | We investigated an effect of extremely low frequency magnetic field (ELF-MF, 60 Hz) oil hyperalgesia using hot plate test. The level of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) were measured to determine if ELF-MF is engaged in NO mediated pain mechanism. Additionally, the involvement of Ca2+-dependent NO pathway in ELF-MF induced hyperalgesia was evaluated by blocking Ca2+ sources with NMDA receptor antagonist and Ca2+ channel blocker. The exposure of mice to ELF-MF lowered pain threshold and elevated NO synthesis in brain and spinal cord. An NOS inhibitor blocked these effects of ELF-MF with attenuating the reduction of pain threshold and the rise of NO level in brain and spine by the exposure of ELF-MF. The hyperalgesic effects of ELF-MF were also blocked by a Ca2+ channel blocker, nimodipine, but not by a NMDA receptor antagonist, MK-801. The expression of Ca2+-dependent nNOS and eNOS and Ca2+-independent iNOS were not changed by ELF-MF. These results indicated that the exposure of ELF-MF might cause Ca2+-dependent NOS activation, which then induces hyperalgesia with the increase in NO synthesis. In conclusion, ELF-MF may produce hyperalgesia by modulating NO synthesis via Ca2+-dependent NOS. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.lfs.2005.07.006 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.78, no.13, pp 1407 - 1412 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000235651400002 | - |
dc.identifier.scopusid | 2-s2.0-32544440038 | - |
dc.citation.endPage | 1412 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1407 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 78 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | extremely low frequency magnetic field | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | hyperalgesia | - |
dc.subject.keywordPlus | ACUTE THERMAL HYPERALGESIA | - |
dc.subject.keywordPlus | METHYL-D-ASPARTATE | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | SYNTHASE ACTIVITY | - |
dc.subject.keywordPlus | CEPAEA-NEMORALIS | - |
dc.subject.keywordPlus | LAND SNAIL | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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