Effects of catechol-O-methyltransferase VaII58Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, DH | - |
dc.contributor.author | Kee, BS | - |
dc.contributor.author | Min, KJ | - |
dc.contributor.author | Lee, YS | - |
dc.contributor.author | Na, C | - |
dc.contributor.author | Park, DB | - |
dc.contributor.author | Lyoo, IK | - |
dc.date.available | 2019-05-30T07:34:10Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.issn | 1473-558X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24427 | - |
dc.description.abstract | We assessed catechol-O-methyltransferase (COMT) polymorphism in 132 first-onset schizophrenic patients and 80 healthy controls. The relationship between COMT polymorphism and cognitive function, aggression and psychiatric symptoms was tested in the schizophrenic group. COMTL carrier had higher digit span score and lower similarity score than COMTH homozygote. COMTL carrier had higher attention and delusion scores and lower inappropriate affect scores than COMTH homozygote. Attention and delusion scores of COMTL allele were higher than COMTH allele. COMTL group had higher aggression than COMTH homozygote. Our results support the theory that COMTL allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Effects of catechol-O-methyltransferase VaII58Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/01.wnr.0000192740.38653.91 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, v.17, no.1, pp 95 - 99 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000234527700020 | - |
dc.identifier.scopusid | 2-s2.0-29344445854 | - |
dc.citation.endPage | 99 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.title | NEUROREPORT | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | aggression | - |
dc.subject.keywordAuthor | attention | - |
dc.subject.keywordAuthor | catechol-O-methyltransferase | - |
dc.subject.keywordAuthor | cognitive stability | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | WORKING-MEMORY | - |
dc.subject.keywordPlus | PREFRONTAL COGNITION | - |
dc.subject.keywordPlus | COMT POLYMORPHISM | - |
dc.subject.keywordPlus | MET GENOTYPE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.