Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1(G93A) transgenic mice
DC Field | Value | Language |
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dc.contributor.author | Chung, YH | - |
dc.contributor.author | Joo, KM | - |
dc.contributor.author | Lim, HC | - |
dc.contributor.author | Cho, MH | - |
dc.contributor.author | Kim, D | - |
dc.contributor.author | Lee, WB | - |
dc.contributor.author | Cha, CI | - |
dc.date.available | 2019-05-30T07:37:37Z | - |
dc.date.issued | 2005-07 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24564 | - |
dc.description.abstract | In the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (PERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation. (C) 2005 Elsevier B.V All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1(G93A) transgenic mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.brainres.2005.05.060 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH, v.1050, no.1-2, pp 203 - 209 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000231127200026 | - |
dc.identifier.scopusid | 2-s2.0-21544444452 | - |
dc.citation.endPage | 209 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 203 | - |
dc.citation.title | BRAIN RESEARCH | - |
dc.citation.volume | 1050 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | amyotrophic lateral sclerosis (ALS) | - |
dc.subject.keywordAuthor | extracellular signal-regulated kinases (ERK) | - |
dc.subject.keywordAuthor | SOD1(G93A) mutant transgenic mice | - |
dc.subject.keywordAuthor | astrocyte | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | CU/ZN SOD MUTATION | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE MUTATION | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | EVENT-RELATED POTENTIALS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | EXPRESS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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