The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail- induced apoptosis in HeLa cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Myoung Woo | - |
dc.contributor.author | Bach, Jae Hyung | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Lee, Do Yeon | - |
dc.contributor.author | Joo, Wan Seok | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Park, Soon Cheol | - |
dc.contributor.author | Kim, Kyung Yong | - |
dc.contributor.author | Lee, Won Bok | - |
dc.contributor.author | Kim, Sung Su | - |
dc.date.available | 2019-05-30T08:33:39Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0735-7907 | - |
dc.identifier.issn | 1532-4192 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24700 | - |
dc.description.abstract | Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) serves as an extracellular signal that triggers apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we investigated the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in HeLa cell death. Here we show that TRAIL-activated ERK1/2 through a tyrosine kinase-dependent pathway, subsequently elevated antiapoptotic Bcl-2 protein levels. ERK1/2 inhibition with PD98059 promoted apoptotic cell death through the downregulation of ERK1/2 activity and Bcl-2 protein levels. Moreover, tyrosine kinase inhibition with Genistein in TRAIL-induced apoptosis effectively attenuated ERK1/2 activity and enhanced apoptotic cell death. Taken together, our results indicate that ERK1/2 activation via tyrosine kinase pathway plays a protective role as the cellular defense mechanism through the upregulation of Bcl-2 protein levels in TRAIL-induced apoptosis. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail- induced apoptosis in HeLa cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/07357900500283036 | - |
dc.identifier.bibliographicCitation | CANCER INVESTIGATION, v.23, no.7, pp 586 - 592 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000234072600004 | - |
dc.identifier.scopusid | 2-s2.0-33344476441 | - |
dc.citation.endPage | 592 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 586 | - |
dc.citation.title | CANCER INVESTIGATION | - |
dc.citation.volume | 23 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | ERK1/2 | - |
dc.subject.keywordAuthor | tyrosine kinase | - |
dc.subject.keywordAuthor | Bcl-2 protein | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | CYTOTOXIC LIGAND TRAIL | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | PROMOTES SURVIVAL | - |
dc.subject.keywordPlus | DEPENDENT PATHWAY | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.