Detailed Information

Cited 34 time in webofscience Cited 42 time in scopus
Metadata Downloads

Distribution and prevalence of human papillomavirus genotypes in routine Pap smear of 2,470 Korean women determined by DNA chip

Full metadata record
DC Field Value Language
dc.contributor.authorHwang, HS-
dc.contributor.authorPark, M-
dc.contributor.authorLee, SY-
dc.contributor.authorKwon, KH-
dc.contributor.authorPang, MG-
dc.date.available2019-05-30T08:34:31Z-
dc.date.issued2004-12-
dc.identifier.issn1055-9965-
dc.identifier.issn1538-7755-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24730-
dc.description.abstractPurpose: We examined human papillomavirus (HPV) genotype distribution and prevalence from routine Pap smear cases in Korean women using DNA Chip. Patients and Methods: A total of 2,470 cervical specimens from women attending routine Pap smear cytology screening in local hospitals was subjected to HPV test. HPV detection and genotyping were done using DNA Chip. Results: HPV DNA was detected in 44.8% of the patients and in 58.7% of the 861 atypical lesions based on the Bethesda system, including 52.6% of 627 atypical squamous cells of undetermined significance (ASCUS), 69.0% of 168 low-grade squamous intraepithelial lesions (LSIL), and 89.4% of 66 high-grade squamous intraepithelial lesions (HSIL) cases. The most frequently found genotypes in all HPV-positive cases were HPV-16, HPV-52, and HPV-58. HPV-16 was the most prevalent type in within normal limits, ASCUS, and HSIL categories, whereas HPV-51 was most frequently found in LSIL. Multiple infection was identified in about 20%, of HPV-positive cases and most of them were that by two different types. HPV-16 was present in the majority of multiple infection cases. A significant decrease in the percentage of multiple infection was observed in HSIL cases compared with ASCUS and LSIL. Conclusions: The distribution of HPV genotypes in Korean women was revealed to have differences to that of other regions, showing higher frequencies of HPV-52, HPV-58, and HPV-51. HSIL cases were mostly infected by sole HPV-16 whereas LSIL that by various HPV types, suggesting a certain type may become dominant over others as the disease progresses.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherAMER ASSOC CANCER RESEARCH-
dc.titleDistribution and prevalence of human papillomavirus genotypes in routine Pap smear of 2,470 Korean women determined by DNA chip-
dc.typeArticle-
dc.identifier.bibliographicCitationCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v.13, no.12, pp 2153 - 2156-
dc.description.isOpenAccessN-
dc.identifier.wosid000226077100025-
dc.identifier.scopusid2-s2.0-11144244763-
dc.citation.endPage2156-
dc.citation.number12-
dc.citation.startPage2153-
dc.citation.titleCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION-
dc.citation.volume13-
dc.type.docTypeArticle-
dc.publisher.location미국-
dc.subject.keywordPlusHPV OLIGONUCLEOTIDE MICROARRAY-
dc.subject.keywordPlusINVASIVE CERVICAL-CANCER-
dc.subject.keywordPlusLESIONS-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusMETAANALYSIS-
dc.subject.keywordPlusTYPE-18-
dc.subject.keywordPlusAGE-
dc.relation.journalResearchAreaOncology-
dc.relation.journalResearchAreaPublic, Environmental & Occupational Health-
dc.relation.journalWebOfScienceCategoryOncology-
dc.relation.journalWebOfScienceCategoryPublic, Environmental & Occupational Health-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Pang, Myung Geol photo

Pang, Myung Geol
대학원 (동물생명공학과.)
Read more

Altmetrics

Total Views & Downloads

BROWSE