The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-alpha
DC Field | Value | Language |
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dc.contributor.author | Yoo, YG | - |
dc.contributor.author | Cho, S | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Lee, MO | - |
dc.date.available | 2019-05-30T08:34:43Z | - |
dc.date.issued | 2004-11 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.issn | 1873-3468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24738 | - |
dc.description.abstract | Hepatitis B virus X protein (HBx) of the hepatitis B virus is strongly implicated in angiogenesis and metastasis during hepatocarcinogenesis. Previously, we reported that HBx enhances activity of hypoxia-inducible factor-1alpha (HIF-1alpha), a potent transactivator that induces angiogenic factors. Here, we delineate the structural region of HBx that potentiates HIF-1alpha. The carboxy-terminus of HBx increased the stability of HIF-1a protein, probably through inhibiting interaction with von Hippel-Lindau protein. Further, the carboxy-terminus of HBx enhanced the transactivation function of HIF-1alpha by enhancing its association with CREB binding protein (CBP). Finally, we demonstrated the physical association of HBx with the basic helix-loop-helix/PER-ARNT-SIM domain, the inhibitory domain, and the carboxy-terminal transactivation domain of HIF-1alpha in vivo. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-alpha | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2004.10.004 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.577, no.1-2, pp 121 - 126 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000225128600021 | - |
dc.identifier.scopusid | 2-s2.0-7544220200 | - |
dc.citation.endPage | 126 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 121 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 577 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | hepatitis B virus X protein | - |
dc.subject.keywordAuthor | hypoxia-inducible factor-1 alpha | - |
dc.subject.keywordAuthor | hepatitis B virus | - |
dc.subject.keywordPlus | HUMAN HEPATOCELLULAR CARCINOMAS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVITY | - |
dc.subject.keywordPlus | CARRIER PATIENTS | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | HEPATOCARCINOGENESIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | KINASE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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