Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells
DC Field | Value | Language |
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dc.contributor.author | Choi, WT | - |
dc.contributor.author | Youn, YC | - |
dc.contributor.author | Han, ES | - |
dc.contributor.author | Lee, CS | - |
dc.date.available | 2019-05-30T08:35:06Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.issn | 1573-6903 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24753 | - |
dc.description.abstract | The present study investigated the effect of 1-methylated beta-carbolines ( harmaline, harmalol and harmine) on change in the mitochondrial membrane permeability and cell death due to reactive nitrogen species in differentiated PC12 cells. beta-Carbolines, caspase inhibitors (z-LEHD. fmk and z-DQMD. fmk) and antioxidants (N-acetylcysteine, dithiothreitol, melatonin, carboxy-PTIO and uric acid) depressed cell viability loss due to 3-morpholinosydnonimine (SIN-1) in PC12 cells. beta-Carbolines inhibited the nuclear damage, the decrease in mitochondrial transmembrane potential, the cytochrome c release, the formation of reactive oxygen species and the depletion of GSH caused by SIN-1 in PC12 cells. beta-Carbolines decreased the SIN-1-induced formations of 3-nitrotyrosine, malondialdehyde and carbonyls in PC12 cells. The results show that 1-methylated beta-carbolines attenuate SIN-1-induced mitochondrial damage. This results in the inhibition of caspase-9 and -3 and apoptotic cell death in PC12 cells by suppressing the toxic actions of reactive oxygen and nitrogen species, including the GSH depletion. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KLUWER ACADEMIC/PLENUM PUBL | - |
dc.title | Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1023/B:NERE.0000042206.46554.e4 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, v.29, no.10, pp 1807 - 1816 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000223983800003 | - |
dc.identifier.scopusid | 2-s2.0-4644233834 | - |
dc.citation.endPage | 1816 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1807 | - |
dc.citation.title | NEUROCHEMICAL RESEARCH | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | differentiated PC12 cells | - |
dc.subject.keywordAuthor | 1-methylated beta-carbolines | - |
dc.subject.keywordAuthor | mitochondrial membrane permeability | - |
dc.subject.keywordAuthor | reactive nitrogen species | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | BRAIN MITOCHONDRIA | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | HARMALINE | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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